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A comparative study of the biological properties of krait (genus Bungarus) venoms

Tan NH, Ponnudurai G

Comp Biochem Physiol C Comp Pharmacol Toxicol, 1990;95(1):105-9.
PMID: 1971550

1. The intravenous median lethal doses (LD50), protease, phosphodiesterase, alkaline phosphomonoesterase, L-amino acid oxidase, acetylcholinesterase, phospholipase A, 5'-nucleotidase, hyauronidase and anticoagulant activities of fourteen samples of venoms from the four common species of krait (Bungarus caeruleus, Bungarus candidus, Bungarus multicinctus and Bungarus fasciatus) were examined. 2. The results indicate that even though there are individual variations in the biological properties of the krait venoms, interspecific differences in the properties can be used for differentiation of the venoms from the four species of Bungarus. Particularly useful for this purpose are the LD50's and the contents of 5'-nucleotidase and hyaluronidase of the venoms.
A comparative study of the biological properties of Australian elapid venoms

Tan NH, Ponnudurai G

Comp Biochem Physiol C Comp Pharmacol Toxicol, 1990;97(1):99-106.
PMID: 1981349

1. The hemorrhagic, procoagulant, anticoagulant, protease, phosphodiesterase, alkaline phosphomonoesterase, L-amino acid oxidase, acetylcholinesterase, arginine ester hydrolase, phospholipase A, 5'-nucleotidase and hyaluronidase activities of 39 samples of venoms from 13 species (15 taxa) of Australian elapids were determined and the Sephadex G-75 gel filtration patterns for some of the venoms were also examined. 2. The results indicate that Australian elapid venoms can be divided into two groups: procoagulant Australian venoms (including N. scutatus, N. ater, O. scutellatus, O. microlepidotus, P. porphyriacus, T. carinatus, H. stephensii and P. textilis) and non-procoagulant Australian venoms (including A. superbus, P. colletti, P. australis, P. guttatus and A. antarcticus). 3. The non-procoagulant Australian venoms exhibited biological properties similar to other elapid venoms, while the procoagulant Australian venoms exhibited some properties characteristic of viperid venoms. 4. The data show that information on venom biological properties can be used for differentiation of many species of Australian elapids. 5. Particularly useful for this purpose are the hyaluronidase, alkaline phosphomonoesterase, acetylcholinesterase, and the procoagulant activities and the Sephadex G-75 gel filtration patterns of the venoms.
Fulltext Immunohistochemical localization of RET rearrangements in a Malaysian papillary thyroid carcinoma population

Omar E, Othman NH

Med J Malaysia, 2003 Aug;58(3):461-2.
PMID: 14750392
Fulltext Measurement and Mapping of Wi-Fi Radiation Level at Hamdan Tahir Library, Universiti Sains Malaysia Health Campus

Supardi, N. F., Mohd Taib, N. H., Abu Amat, N. H., Yusoff, M. N. S.

Physics and Technology in Medicine, 2020;1(1):52-57.
MyJurnal

Wi-Fi is a wireless communication technology that uses specific electromagnetic frequencies. The increasing use of Wi-Fi has raised public concerns about the impact of electromagnetic radiation on the environment and human health. Since the exposure level of the electromagnetic field (EMF) radiation differs between different locations, it is important to measure the strength of the EMF at various locations under observation. This study aimed to obtain specific values related to the radiofrequency and microwave EMF which is described by four specific parameters, that are 1) the frequency of the wave, 2) the electric field strength E, 3) the magnetic field strength H, and 4) the power density S. This study was carried out at the first floor area of Hamdan Tahir Library, Universiti Sains Malaysia Health Campus. Mapping of Wi-Fi signal and measurement of Wi-Fi radiation level was performed at four specific locations, that are Laptop zone 1, Laptop zone 2, Computer lab, and Cozy corner. The average radiation level was compared with the ICNIRP standard limit for public user. It was observed that the Wi-Fi signal was highest in Laptop zone 2 followed by Laptop zone 1 which displayed a moderate signal strength. Whereas moderate but lower signal level was detected in Computer lab zone and Cozy corner. The electric and magnetic fields as well as power density were found highest in Laptop zone 1, followed by Laptop zone 2, Cozy corner, and Computer lab. Comparison with standard ICNIRP limit showed that the radiation level is still far below the ICNIRP limit, which is only 2% of exposure level. To conclude, Laptop zone 2 exhibited the strongest Wi-Fi signal whereas Laptop zone 1 displayed the highest radiation level. However, the strength of the electric and magnetic fields as well as power density is still far below the ICNIRP limit.
Fulltext Measurement and Mapping of Wi-Fi Radiation Level at Students Hostel in Universiti Sains Malaysia Health Campus

Abu Amat, N. H., Mohd Taib, N. H., Supardi, N. F., Yusoff, M. N. S.

Physics and Technology in Medicine, 2020;1(1):38-44.
MyJurnal

The increasing use of wireless communication devices, particularly Wi-Fi has raised public concerns on the exposure to electromagnetic field (EMF) and its possible effect on human health. As the exposure level of the EMF radiation varies between different locations, measurement of the EMF strength at various locations is vital. In this study, we aimed to measure the EMF exposure which is described by four specific parameters, specifically 1) the frequency of the wave, 2) the electric field strength E, 3) the magnetic field strength H, and 4) the power density S. This study was performed at the second floor in Nurani hostel block in Desasiswa Murni Nurani, Universiti Sains Malaysia Health Campus. Mapping of Wi-Fi signal and measurement of Wi-Fi radiation level was performed at four specific locations, that are in a student room, television room, prayer room, and ironing room. The average radiation level was compared with the standard limit set by International Commission on Non-Ionizing Radiation Protection (ICNIRP). It was observed that the strength of Wi-Fi signal was highest in students’ room followed by television room. Both of these rooms exhibited high signal strength. While moderate but lower signal level was observed in prayer room followed by ironing room. The electromagnetic field and power density were found highest in students’ room, followed by television room, prayer room, and ironing room. Comparison with standard ICNIRP limit showed that the radiation level is still far below the acceptable limit, which is only 2% of the exposure level. To conclude, students’ room exhibited the strongest Wi-Fi signal and the highest radiation level. However, the radiation level especially power density is still far below the ICNIRP limit.
In vivo interactions between neurotoxin, cardiotoxin and phospholipases A2 isolated from Malayan cobra (Naja naja sputatrix) venom

Tan NH, Armugam A

Toxicon, 1990;28(10):1193-8.
PMID: 2264068

The in vivo interactions between alpha-neurotoxin, cardiotoxin and two phospholipases A2 (sputa-phospholipase A2-1 and 3) isolated from Malayan cobra venom were assessed by examining the effects of simultaneous injection of sub-LD50 dose of one toxin on (i) i.v. LD50 S of the other toxins in mice; and (ii) mean survival times of mice injected with lethal doses of the other toxins. While LD50 measurements did not reveal any interaction between the toxins in vivo, survival time measurements suggest a synergy between the neurotoxin and sputa-phospholipase A2-1 and between sputa-phospholipase A2-1 and sputa-phospholipase A2-3. Our results also suggest that both sputa-phospholipases A2 interfere with the lethal action of the cardiotoxin, resulting in prolongation of the mean survival time of mice injected with a lethal dose of cardiotoxin. The patterns of in vivo interactions between phospholipase A2 and other venom toxins appear to depend on the nature and mode of pharmacological action of the phospholipase A2.
An investigation on the antigenic cross-reactivity of Calloselasma rhodostoma (Malayan pit viper) venom hemorrhagin, thrombin-like enzyme and L-amino acid oxidase using enzyme-linked immunosorbent assay

Tan NH, Ponnudurai G

Toxicon, 1994 Oct;32(10):1265-9.
PMID: 7846697

Indirect ELISA shows that the antibodies to Calloselasma rhodostoma venom hemorrhagin (CR-HMG), thrombin-like enzyme (CR-TLE) and L-amino acid oxidase (CR-LAAO) exhibited strong to moderate cross-reactions with most crotalid and viperid venoms, but only anti-CR-LAAO cross-reacted with the elapid venoms. However, the indirect ELISA failed to detect some antigenic similarities demonstrable by cross-neutralization study. The double-sandwich ELISA for the three anti-C. rhodostoma venom components exhibited a much lower level of cross-reactions than the indirect ELISA.
Fulltext Changing habits and attitudes towards smoking among future physicians

Tee GH, Noran NH, Farizah H, Azhana NH

Med J Malaysia, 2007 Dec;62(5):383-7.
PMID: 18705471

This study was conducted to asses the future physicians' habits, knowledge and attitude towards smoking. These factors influence the credibility of future Malaysian physicians as advocators and treatment providers. A cross sectional study was carried out among medical students at the Medical Faculty, University Malaya. Knowledge on smoking was evaluated on the total scores for knowledge questions, with one point and zero for each correct and incorrect answer respectively, to a maximum of six potential points. Attitude towards smoking was measured by summation of scores on attitude items; each item was scored from five points for "against smoking" and one point for "favourable to smoking". The possible score ranged from 10 to 50. The response rate was 79.4%. Prevalence of overall smokers was 4.4%. The mean knowledge score among smokers (4.30 +/- 2.17) was significantly lower than nonsmokers (5.19 +/- 1.28). The mean attitude score was higher among non-smokers (44.30 +/- 6.54) than smokers (39.86 +/- 10.93). The result from this study showed that smoking prevalence was lower compared to previous studies done in Malaysia.
Fulltext Factors influencing consumers’ knowledge towards contaminated peanut-based products

Hassan, N. A., Kamarulzaman, N. H., Mohd Nawi, N.

International Food Research Journal, 2018;25(102):147-156.
MyJurnal

Food products contamination has become a huge global issue, mostly related to foodborne diseases. Morbidity and mortality are on the increase worldwide due to the increasing incidence of foodborne diseases. Peanut-based products are reported to contribute significantly to food contamination issues. It needs to be addressed well to make sure consumers are safe from these hazards. Besides, all of the scientific knowledge of food products contaminations symptoms needs to be known not only among scientists but also among consumers. Thus, the objectives of this study are to examine consumers’ knowledge level towards contaminated peanut-based products and to determine factors influencing consumers’ knowledge towards consuming contaminated peanut-based products. A survey using a structured questionnaire was carried out among 1,263 respondents who consumed peanut and peanut-based products in daily, weekly or monthly diet at Klang Valley area. The results from this study showed that about 73.9% of total respondents have inadequate knowledge and only 26.1% have adequate knowledge towards the issue of contaminated peanut-based products. The results also indicated that there are five factors (mass media, practicing standard, packaging information, experience, and official government website) that greatly influenced consumers’ knowledge towards the issue of contaminated peanut-based products. Consumers who have lack knowledge of the danger in consuming contaminated peanuts-based products are at risk of adverse health effects if consumed in a long term. Hence, the government and NGOs need to carry out campaigns that would increase awareness among consumers towards the risks of consuming contaminated peanut-based products.
Fulltext Muslim consumers’ awareness and perception of Halal food fraud

Kamarulzaman, N. H., Ruslan, A. A. A., Sanny, M.

International Food Research Journal, 2018;25(101):87-96.
MyJurnal

Halal is an important aspect of food selection as it is one’s part to obey religious obligations and commandments. Since the halal food industry covers the farm-to-table operations, therefore unwanted practices which culminate to halal food fraud along food supply chain has become a major concern among Muslim consumers. This is because food fraud is a subjective concept, hence objective verification of fraudulent activities and the extent of fraud could be difficult to verify. The current study was therefore carried out to determine Muslim consumers’ awareness and perceptions towards halal food fraud. A total of 352 respondents from Klang Valley areas were randomly selected to be the target respondents in this study. The data obtained were analyzed using descriptive analysis, chi-square analysis, and factor analysis. The results indicated that most of the respondents (96.9%) in Klang Valley areas were aware of halal food fraud issues. The findings also showed that gender, age, education level, and occupation had significant relationships with awareness of halal food fraud. Three factors were classified as influential to Muslim consumers’ perception towards halal food fraud namely halal logo, labeling and packaging, authorities’ exposure and enforcement as well as consumer attitude. The study recommended that Islamic authorities should continuously seek ways to improve and educate consumers towards halal food fraud while the government should further strengthen their important role of enforcing law and penalties to irresponsible industry players.
Fulltext EFFECTS OF TANK COLOUR ON BODY COLOUR INTENSITY AND GROWTH OF YELLOW GOURAMI Trichopodus trichopterus

Asra Nor Izaty, A., Norazmi-Lokman, N. H.

UMT Journal of Undergraduate Research, 2019;1(4):9-18.
MyJurnal

Yellow gourami (Trichopodus trichopterus) is a species native to Southeast Asia and is famous as ornamental species. However, hobbyists and farmers encounter problems where its body colour easily becomes faded in captivity. Since colour enhancer pellets are expensive, an experiment was performed to determine whether tank colour can influence the body colour intensity and growth of T. trichopterus. Four different tank colours (white, yellow, blue and green) with five replicates were tested where fish were kept under natural lighting (outdoor) conditions for two months. The results demonstrated that fish reared in green coloured tank showed an increment in its colour intensity while fish reared in white tanks increased its body weight. It can be concluded that tank colour does affect the body colour intensity and weight of T. trichopterus. This study will help farmers and hobbyists to solve colour fading problem using a cheaper way.
A malaria survey in the Malay Archipelago

Swellengrebel NH, Swellengrebel-de Graaf JMH

Parasitology, 1920;12:180-198.
DOI: 10.1017/S0031182000014177
Observations on the larva destroying action of small fish in the Malay Archipelago

Swellengrebel NH, Swellengrebel-de-Graaf JMH

J Trop Med Hyg, 1920;23:77-9.
Characterization of un-plasticized and propylene carbonate plasticized carboxymethyl cellulose doped ammonium chloride solid biopolymer electrolytes

Ahmad NH, Isa MIN

Carbohydr Polym, 2016 Feb 10;137:426-432.
PMID: 26686147 DOI: 10.1016/j.carbpol.2015.10.092

Two solid biopolymer electrolytes (SBEs) systems of carboxymethyl cellulose doped ammonium chloride (CMC-AC) and propylene carbonate plasticized (CMC-AC-PC) were prepared via solution casting technique. The ionic conductivity of SBEs were analyzed using electrical impedance spectroscopy (EIS) in the frequency range of 50 Hz-1 MHz at ambient temperature (303K). The highest ionic conductivity of CMC-AC SBE is 1.43 × 10(-3)S/cm for 16 wt.% of AC while the highest conductivity of plasticized SBE system is 1.01 × 10(-2)S/cm when added with 8 wt.% of PC. TGA/DSC showed that the addition of PC had increased the decomposition temperature compared of CMC-AC SBE. Fourier transform infrared (FTIR) spectra showed the occurrence of complexation between the SBE components and it is proved successfully executed by Gaussian software. X-ray diffraction (XRD) indicated that amorphous nature of SBEs. It is believed that the PC is one of the most promising plasticizer to enhance the ionic conductivity and performance for SBE system.
Fulltext Spontaneous calf haematoma: case report

Zubaidah NH, Liew NC

Med J Malaysia, 2014 Feb;69(1):44-5.
PMID: 24814632 MyJurnal

Spontaneous calf haematoma is a rare condition and few case reports have been published in the English literature. Common conditions like deep vein thrombosis and traumatic gastrocnemius muscle tear need to be considered when a patient presents with unilateral calf swelling and tenderness. Ultrasound and Magnetic Resonance Imaging are essential for confirmation of diagnosis. The purpose of this paper is to report on a rare case of spontaneous calf hematoma and its diagnosis and management.
Fulltext The association between body mass index and age related cataract

Noran NH, Nooriah S, Mimiwati Z

Med J Malaysia, 2007 Mar;62(1):49-52.
PMID: 17682571 MyJurnal

This study was carried out to determine the association between body mass index and age related cataract among patients attending eye clinic. We conducted a case control study. The outcome of clinical eye assessment determined the patient's status. Mean body mass index among the cases was shown to be higher (25.4 +/- 4.5) than the control group (24.4 +/- 3.9) (p < 0.01). Crude analysis showed that only obese respondents were 2.4 times more likely to develop age related cataract, however this association was not seen in the multivariate analysis after adjusting for other determinants (aOR 1.81; 95% CI 0.91 - 3.62). We conclude that there is no association between body mass index and age related cataract.
Study site: Eye clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
Relationship between reproductive exposures and age-related cataract in women

Noran NH, Salleh N, Zahari M

Asia Pac J Public Health, 2007;19(2):23-8.
PMID: 18050560

The objective of this study is to evaluate the relationship between reproductive exposures and age-related cataract among women. This was a hospital based case-control study. The study population included female patients, aged 50 years and above who attended the Eye clinic at the University of Malaya Medical Centre. The outcome measurement was based on ophthalmologic examination by an ophthalmologist. The data on exposure was obtained from face to face interview using a structured questionnaire. In order to reduce the recall bias, patients' medical records were used to substantiate the exposure status. Multiple logistic regression was used to assess the association of age-related cataract with exogenous estrogen usage (HRT and OCP) and duration of menses. Important confounders such as age, history of diabetes, cigarette smoking and steroids usage were controlled for in the analysis. Females with 29 years or less of endogenous estrogen exposure of, have almost three times the risk of developing age related cataract (adjusted OR 3.42: 95% CI: 1.28, 9.16), similarly among those with exposure of 30-32 years (adjusted OR 3.64: 95% CI: 1.08, 12.26). Hormone Replacement Therapy used for more than three years was found to be a protective factor of age-related cataract. There is evidence that reproductive exposure may play a role in reducing the occurrence of age-related cataract among Malaysian women.
Study site: Eye clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
Differentiation of stem cells derived from carious teeth into dopaminergic-like cells

Gnanasegaran N, Govindasamy V, Abu Kasim NH

Int Endod J, 2016 Oct;49(10):937-49.
PMID: 26354006 DOI: 10.1111/iej.12545

AIM: To investigate whether dental pulp stem cells from carious teeth (DPSCs-CT) can differentiate into functional dopaminergic-like (DAergic) cells and provide an alternative cell source in regenerative medicine.
METHODOLOGY: Dental pulp stem cells from healthy (DPSCs) and carious teeth (DPSCs-CT) were isolated from young donors. Both cell lines were expanded in identical culture conditions and subsequently differentiated towards DAergic-like cells using pre-defined dopaminergic cocktails. The dopaminergic efficiencies were evaluated both at gene and protein as well as at secretome levels.
RESULTS: The efficiency of DPSCs-CT to differentiate into DAergic-like cells was not equivalent to that of DPSCs. This was further reflected in both gene and protein generation whereby key neuronal markers such as nestin, NURR1 and beta-III-tubulin were expressed significantly lower as compared to differentiated DPSCs (P
Fulltext Suboptimal Therapy for Dyslipidaemia in Coronary Bypass Surgical Patients with Premature Ischaemic Heart Disease

Yong Sheng Tan NH, Sachithanandan A

Med J Malaysia, 2015 Apr;70(2):114-5.
PMID: 26162393 MyJurnal

The incidence of premature multi-vessel coronary artery disease (CAD) is on the rise in Malaysia. The pathogenesis of coronary atherosclerosis is multi-factorial with dyslipidaemia being one such risk factor. Elevated total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) levels are primarily responsible. We analysed the fasting pre-operative lipid profiles of coronary artery bypass graft (CABG) patients with symptomatic severe premature CAD. A majority of patients had an elevated LDL cholesterol level despite being on a statin. Similarly, no patient with an elevated TG level was prescribed a fibrate. Pre-operative control of known dyslipidaemia was suboptimal in young adults with angiographially proven severe symptomatic CAD. This is either due to subtherapeutic dose prescribing or failure to commence appropriate anti-lipid drugs. Collectively, general practitioners, cardiologists and cardiac surgeons must be more diligent in monitoring lipid profiles in such patients and be more meticulous in prescribing therapeutic doses to achieve target control.
Evaluation and application of a simple and rapid method for the analysis of aflatoxins in commercial foods from Malaysia and the Philippines

Ali N, Hashim NH, Yoshizawa T

Food Addit Contam, 1999 Jul;16(7):273-80.
PMID: 10656052

For application to the analysis of aflatoxins (AF) in commercial peanut and corn products, the ISOLUTE multimode column (IMC, solid phase multifunctional column) method was validated by comparing with the modified Florisil column (MFC) method. Twenty-two peanut and eight corn products from Malaysia and the Philippines were analysed for AFB1, AFB2, AFG1 and AFG2 firstly by the MFC method and then by the IMC method. For peanut products, 14 out of 22 samples were positive by the two methods in the range of 1-378 micrograms/kg of AF, and correlation coefficients (r) for AFB1 and AFB2 were 0.987 and 0.997, respectively. For corn and corn products, all the samples were positive in the range of 1-130 micrograms/kg, and r values were 0.992 and 0.805 for AFB1 and AFB2 respectively. Thus, the results were significantly (p < 0.01) in close agreement, particularly for lower range of 1-50 micrograms/kg of AF concentrations in all the samples. For the occurrence of AF, 11 (65%) of peanut products from Malaysia were contaminated with AF at a mean level of 50 micrograms/kg (maximum 180 micrograms/kg) and two (40% products from the Philippines were contaminated with as high as 375 micrograms/kg and 177 micrograms/kg of AF, respectively. All the corn products from the Philippines were contaminated with AF at a mean level of 44 micrograms/kg (maximum 130 micrograms/kg). Contamination of commercial foods with high levels of AF is a very important issue to both the countries since these foods are very popular among children.

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