Displaying publications 241 - 260 of 2121 in total

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  1. Lancet, 1952 Jan 19;1(6699):144.
    PMID: 14889790
    Matched MeSH terms: Biomedical Research*
  2. Shitan, Mahendran, Kok, Wei Ling
    MyJurnal
    Modelling observed meteorological elements can be useful. For instance, modelling rainfall has
    been an interest for many researchers. In a previous research, trend surface analysis was used and
    it was indicated that the residuals might spatially be correlated. When dealing with spatial data, any
    modelling technique should take spatial correlation into consideration. Hence, in this project, fitting
    of spatial regression models, with spatially correlated errors to the annual mean relative humidity
    observed in Peninsular Malaysia, is illustrated. The data used in this study comprised of the annual
    mean relative humidity for the year 2000-2004, observed at twenty principal meteorological stations
    distributed throughout Peninsular Malaysia. The modelling process was done using the S-plus
    Spatial Statistics Module. A total of twelve models were considered in this study and the selection
    of the model was based on the p-value. It was found that a possible appropriate model for the
    annual mean relative humidity should include an intercept and a term of the longitude as covariate,
    together with a conditional autoregressive error structure. The significance of the coefficient of the
    covariate and spatial parameter was established using the Likelihood Ratio Test. The usefulness
    of the proposed model is that it could be used to estimate the annual mean relative humidity at
    places where observations were not recorded and also for prediction. Some other potential models
    incorporating the latitude covariate have also been proposed as viable alternatives.
    Matched MeSH terms: Research; Research Personnel
  3. LAING AB
    Indian J Malariol, 1960 Dec;14:391-408.
    PMID: 13758336
    Matched MeSH terms: Research*
  4. Bergin PS, Beghi E, Sadleir LG, Brockington A, Tripathi M, Richardson MP, et al.
    Epilepsia Open, 2017 Mar;2(1):20-31.
    PMID: 29750210 DOI: 10.1002/epi4.12033
    Objective: EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials.

    Methods: Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification.

    Results: Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70.

    Significance: We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical trials.
    Matched MeSH terms: Research; Research Personnel
  5. Tandon S, Venkiteswaran A, Baliga SM, Nayak UA
    J Indian Soc Pedod Prev Dent, 2017 5 12;35(2):102-105.
    PMID: 28492186 DOI: 10.4103/0970-4388.206038
    Research being an investigative process is employed to increase or revise the current knowledge. Scientific research involves the conduct of a methodical study to prove a hypothesis or give an answer to a specific question with the main aim of finding definitive answer. This paper aims to advance knowledge of research and develop interest in the postgraduate students. It also throws light on the existing and emerging research strengths within a "high-performance culture." The trends in dental research worldwide are looked at, in particular, a comparison between the publication status in two countries, namely India and Australia. The current themes in dental research are also discussed to facilitate future projects for the aspiring pediatric dentists. Stress is given to the importance of evidence-based dentistry as the current times call for high-quality and ethical papers which are devoid of plagiarism. The common reasons for failure of a research are explored and the strengthening factors are highlighted. Proper planning of a pertinent research project is beneficial to the researcher as well as the dental community.
    Matched MeSH terms: Dental Research/trends*
  6. Lawrence RJ
    PMID: 28704943 DOI: 10.3390/ijerph14070763
    The low impact of scientific research on the relations between housing and health during the last 30 years can be attributed to a number of reasons. First, statistical analyses have meant to improve understanding of the relations between what are interpreted and measured as causal factors. However, any single statistical approach fails to account for the dynamic non-linear relations between multiple factors and therefore cannot analyze systemic complexity. Second, there has been too little accumulation and validation of knowledge from scientific research owing to the dominance of cross-sectional studies, and the lack of coordinated research agendas using these approaches in order to confirm empirical findings. Hence, there is little evidence indicating that public policies in both the housing and the public health sectors in specific localities have benefited from the accumulated evidence of empirical research. Third, the findings from empirical studies have been published in academic journals and monographs but rarely disseminated to actors and institutions in the public and private sectors. Hence housing and health research and policy formulation have not been consolidated during the last three decades. The author of this communication argues for a radical shift from conventional disciplinary and multi-disciplinary contributions to transdisciplinary research programmes and projects that formulate and apply innovative approaches founded on conceptual frameworks that apply systems thinking for the integration of knowledge and know-how of researchers, policy makers, and professional practitioners in precise localities.
    Matched MeSH terms: Research; Empirical Research
  7. Mohammadi SH, Norazizan S, Nikkhah HA
    Qual Quant, 2018;52(4):1761-1778.
    PMID: 29937584 DOI: 10.1007/s11135-017-0565-9
    There is a growing consensus among citizens and members of local government that citizen participation is desirable for local government. However in practice, there are differing perceptions between them regarding the level and extent of citizen participation. As citizen participation is a multi faceted concept, its meaning is construed differently by both the members of local government and the citizen groups. This paper attempts to describe the conflicts that arise from participation. The paper is based on the study of the process of citizen participation in local government carried out in Torbat-Heydarieh city, Iran. A qualitative research method is seen as the most suitable approach of collecting and analyzing the data. The method employed for data collection in this research is in-depth interviews. In-depth interviews were conducted to gauge the existence of conflicts regarding participation. The findings reveal four areas that give rise to conflicts. This study also attempts to highlight two different views regarding citizen participation; the people-centered view and authority-centered view.
    Matched MeSH terms: Research Design; Qualitative Research
  8. Balogun WG, Cobham AE, Amin A, Seeni A
    Metab Brain Dis, 2018 10;33(5):1431-1441.
    PMID: 29797116 DOI: 10.1007/s11011-018-0250-2
    Africa is faced with an increasing underrepresentation of her research progress in many fields of science including neuroscience. This underrepresentation stems from the very low investments directed towards research by African governments as these are thought to be high-priced. Scientists and researchers within the continent are left to compete highly for the very limited research grants or choose to fund research from their personal purse. Therefore, presenting a need for all possible strategies to make science and research approaches more affordable in Africa. This paper presents one of such strategy, which advocates the use of invertebrate animal models for neuroscience research in place of the commonly used vertebrate models. Invertebrates are cheaper, more available and easy to handle options and their use is on the rise, even in the developed societies of the world. Here, we investigate the current state of invertebrate neuroscience research in Africa looking at countries and institutions conducting neuroscience research with invertebrates and their publication output. We discuss the factors which impede invertebrate neuroscience research in Africa like lack of research infrastructure and adequate expert scientists and conclude by suggesting solutions to these challenges.
    Matched MeSH terms: Research*
  9. Sharif SP, Mostafiz I, Guptan V
    Nurse Res, 2019 09 21;26(2):28-31.
    PMID: 30207432 DOI: 10.7748/nr.2018.e1577
    BACKGROUND: A growing number of nursing studies have used structural equation modelling (SEM) analysis. However, there is little research assessing the use of SEM analysis in nursing research.

    AIM: To present a systematic review of nursing research that uses SEM.

    DISCUSSION: The review revealed poor reporting of information about the determination of sample size, missing data, normality and outliers. Most studies neither computed composite reliability nor assessed convergent and discriminant validity. There was a lack of consistency in performing the analysis. Some of the studies conducted exploratory factor analysis before performing confirmatory factor analysis, without discussing its necessity. Although most studies declared the estimation method and software used, there were many that did not.

    CONCLUSION: Little information about the different steps of conducting SEM analysis was provided in the studies. Weaknesses and areas of improvement for future empirical SEM studies were identified.

    IMPLICATIONS FOR PRACTICE: When conducting SEM, there are many issues that should be addressed. Overlooking these issues may invalidate findings. The results of this review provide nurse researchers with best practice guidelines for conducting SEM and pave the way for researchers to adopt this method in their studies.

    Matched MeSH terms: Nursing Research*
  10. Seman RNAR, Azam MA, Ani MH
    Nanotechnology, 2018 Dec 14;29(50):502001.
    PMID: 30248022 DOI: 10.1088/1361-6528/aae3da
    Supercapacitors, based on fast ion transportation, are among the most promising energy storage solutions that can deliver fast charging-discharging within seconds and exhibit excellent cycling stability. The development of a good electrode material is one of the key factors in enhancing supercapacitor performance. Graphene (G), an allotrope of carbon that consists of a single layer of carbon atoms arranged in a hexagonal lattice, elicits research attention among scientists in the field of energy storage due to its remarkable properties, such as outstanding electrical conductivity, good chemical stability, and excellent mechanical behavior. Furthermore, numerous studies focus on 2D materials that are analogous to graphene as electrode supercapacitors, including transition metal dichalcogenides (TMDs). Recently, scientists and researchers are exploring TMDs because of the distinct features that make 2D TMDs highly attractive for capacitive energy storage. This study provides an overview of the structure, properties, synthesis methods, and electrochemical performance of G/TMD supercapacitors. Furthermore, the combination of G and TMDs to develop a hybrid structure may increase their energy density by introducing an asymmetric supercapacitor system. We will also discuss the future prospect of this system in the energy field.
    Matched MeSH terms: Research; Research Personnel
  11. Aswadi Mohamad, Zaitul Azma Zainon Hamzah
    MyJurnal
    This article focuses in structure of language within the village society in Manik Urai Kelantan during
    the flood situation. The research was specifically to identify the structure of Speech Act use by the rural
    community to give information about flood. Besides, this research observes the application of
    linguistics methodology during flood situation using Speech Act Theory which is the categorization of
    Speech Act by Searle (1969). This theory was choose for the ability to detail linguistic's differences
    based on the structure of Speech Act categories such as representatives, directives, commissives,
    expresives and declaratives. For the purpose of the research, a video about flood situation was choose
    and transcribe to observe the the structure of speech act within the village society in the flood situation.
    The result of the research shows all Speech Act have their structure. The beneficial of this research is as
    a guideline and reference for the readers and language researchers especially those who were active
    participant of volunteer field.
    Matched MeSH terms: Research; Research Personnel
  12. Ang, Kean Hua
    MyJurnal
    This Methodology framework in research study smoothing the process of collecting data. Research
    study is categorized into qualitative and quantitative research. Qualitative research refer to a studies
    require careful observation, while quantitative research refers to a studies involve in statistics.
    Qualitative and quantitative research study can be determined through primary and secondary data.
    Primary data is defined as data that comes from original or the first source, while secondary data is
    defined as data that has been collected by other researchers. Primary data can be categorized into
    active and passive. Active primary data can be divided into direct interview (through face to face
    between researcher and respondents) and interviewed indirectly (e.g. by phone, mail, technology),
    while passive primary data involve with structured and secret characteristic, structured and open
    characteristic, unstructured and secret characteristic, unstructured and open characteristic. Secondary
    data involves with writing (journals, books, magazines, past records, reports and documents, internet, theses, short stories, newspaper), as well as vision and hearing (speeches, movies and videos, songs,
    stories). Even secondary data has its advantages and disadvantages, but both secondary and primary
    data are depend on each other in solving the society problems through the achievement of the
    objectives or hyphotheses in a research study.
    Matched MeSH terms: Research Personnel; Qualitative Research
  13. Sy Mohamad SF, Mohd Said F, Abdul Munaim MS, Mohamad S, Azizi Wan Sulaiman WM
    Crit Rev Biotechnol, 2020 May;40(3):341-356.
    PMID: 31931631 DOI: 10.1080/07388551.2020.1712321
    Reverse micellar extraction (RME) has emerged as a versatile and efficient tool for downstream processing (DSP) of various biomolecules, including structural proteins and enzymes, due to the substantial advantages over conventional DSP methods. However, the RME system is a complex dependency of several parameters that influences the overall selectivity and performance of the RME system, hence this justifies the need for optimization to obtain higher possible extraction results. For the last two decades, many experimental design strategies for screening and optimization of RME have been described in literature. The objective of this article is to review the use of different experimental designs and response surface methodologies that are currently used to screen and optimize the RME system for various types of biomolecules. Overall, this review provides the rationale for the selection of appropriate screening or optimization techniques for the parameters associated with both forward and backward extraction during the RME of biomolecules.
    Matched MeSH terms: Research Design*
  14. Felix EA, Lee SP
    PLoS One, 2020;15(3):e0229131.
    PMID: 32187181 DOI: 10.1371/journal.pone.0229131
    Predicting the number of defects in software at the method level is important. However, little or no research has focused on method-level defect prediction. Therefore, considerable efforts are still required to demonstrate how method-level defect prediction can be achieved for a new software version. In the current study, we present an analysis of the relevant information obtained from the current version of a software product to construct regression models to predict the estimated number of defects in a new version using the variables of defect density, defect velocity and defect introduction time, which show considerable correlation with the number of method-level defects. These variables also show a mathematical relationship between defect density and defect acceleration at the method level, further indicating that the increase in the number of defects and the defect density are functions of the defect acceleration. We report an experiment conducted on the Finding Faults Using Ensemble Learners (ELFF) open-source Java projects, which contain 289,132 methods. The results show correlation coefficients of 60% for the defect density, -4% for the defect introduction time, and 93% for the defect velocity. These findings indicate that the average defect velocity shows a firm and considerable correlation with the number of defects at the method level. The proposed approach also motivates an investigation and comparison of the average performances of classifiers before and after method-level data preprocessing and of the level of entropy in the datasets.
    Matched MeSH terms: Research Design*
  15. Khor SK
    Public Health Res Pract, 2021 Nov 10;31(4).
    PMID: 34753167 DOI: 10.17061/phrp3142123
    Objectives and importance of study: This study examines how health policy and systems research (HPSR) is funded in eight countries and areas in the World Health Organization Western Pacific Region (WPRO). The aim of the research is to provide a guide for HPSR practitioners and organisations to understand the landscape of research funding priorities across the WPRO and to inform demand generation and advocacy activities for HPSR funding and output.

    STUDY TYPE: Mixed methods.

    METHODS: A desk review was conducted relating to HPSR funding, followed by in-depth interviews. Eight countries and areas were selected to represent characteristics of different health systems. Literature reviews included an analysis of available data relating to HPSR funding and national research and development (R&D) budgets, between 2010 and 2019 (inclusive). In-depth interviews were conducted with 23 stakeholders using an approved interview guide, to assess the attitudes of HPSR funding decision makers towards HPSR, determinants for HPSR and health research funding decisions, and proposals to strengthen HPSR funding and output.

    RESULTS: There are four main characteristics of HPSR funding in the WPRO: 1) a general absence of studies on HPSR funding and its determinants; 2) no universally accepted understanding of HPSR; 3) an absence of granular health research funding data in general and for HPSR in particular; and 4) HPSR funding is generally perceived to be minimal. In-depth interviews show that HPSR has different interpretations and emphases across WPRO countries, leading to a fragmented landscape where decision makers generally favour biomedical or clinical research. Participants indicate that political involvement increases overall research funding, especially if there is a clear connection between funders, producers and HPSR users. Suggestions from participants to strengthen HPSR include: appropriately using central agencies to generate demand and raise HPSR as a national priority; adopting interdisciplinary HPSR; and building HPSR capacity and organisational structures.

    CONCLUSIONS: HPSR in the Western Pacific region is generally not well funded, with biomedical and public health research often perceived as a higher priority. Although funding is a crucial component of the quality, quantity and relevance of HPSR outputs, HPSR practitioners and organisations must also generate demand for HPSR, build capacity for increasing the quantity and quality of HPSR outputs, and build pathways to translate HPSR outputs into real-world policies.

    Matched MeSH terms: Health Services Research*
  16. Yusof MYPM, Teo CH, Ng CJ
    BMC Med Ethics, 2022 Nov 21;23(1):117.
    PMID: 36414962 DOI: 10.1186/s12910-022-00849-x
    BACKGROUND: The research shows a growing trend in using an electronic platform to supplement or replace traditional paper-based informed consent processes. Instead of the traditionally written informed consent document, electronic informed consent (eConsent) may be used to assess the research subject's comprehension of the information presented. By doing so, respect for persons as one of the research ethical principles can be upheld. Furthermore, these electronic methods may reduce potential airborne infection exposures, particularly during the pandemic, thereby adhering to the beneficence and nonmaleficence principle. This scoping review aims to identify the ethics related criteria that have been included in electronic informed consent processes and to synthesize and map these criteria to research ethics principles, in order to identify the gaps, if any, in current electronic informed consent processes.

    METHODS: The search was performed based on internet search and three main databases: PubMed, SCOPUS and EBSCO. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation guideline was used to report this work.

    RESULTS: Of 34 studies that met the inclusion criteria, 242 essential original constructs were collated, and 7 concepts were derived. Digital content showed the highest percentage of collated original constructs (27%, n = 65) followed by accessibility (24%, n = 56), comprehension engagement (18%, n = 43), autonomy (14%, n = 34), confidentiality (11%, n = 25), language (5%, n = 13), and parental consent (1%, n = 2). Twenty-five new items were synthesized for eConsent criteria which may provide guidance for ethical review of research involving eConsent.

    CONCLUSION: The current study adds significant value to the corpus of knowledge in research ethics by providing ethical criteria on electronic informed consent based on evidence-based data. The new synthesized items in the criteria can be readily used as an initial guide by the IRB/REC members during a review process on electronic informed consent and useful to the future preparation of a checklist.

    Matched MeSH terms: Ethics, Research*
  17. Bhagavathula AS, Bandari DK, Tefera YG, Jamshed SQ, Elnour AA, Shehab A
    Pharmacy (Basel), 2017 Oct 11;5(4).
    PMID: 29019923 DOI: 10.3390/pharmacy5040055
    Aim: To assess the attitude of medical and pharmacy students in Asian and African universities towards scholarly research activities. Methods: An anonymous, cross-sectional, self-reported online survey questionnaire was administered to medical and pharmacy students studying in various Asian and African universities through social media between May and July 2016. A 68-item close-ended questionnaire consisting of Likert-scale options assessed the students' research-specific experiences, and their attitudes towards scholarly research publications. Results: A total of 512 questionnaires were completed, with a response rate of 92% from Asia and 94% from Africa. More pharmacy students (70.8%) participated than medical students (29.2%). Overall 52.2% of the pharmacy students and 40% of medical students believed that research activities provided a means of gaining respect from their faculty members. Lack of encouragement, paucity of time, gaps in research activities and practices, and lack of research funding were some of the most common barriers acknowledged by the students. A nonparametric Mann-Whitney test showed that a statistically significant difference was observed, in that more than 80% of the pharmacy students viewed scientific writing and research activities as valuable experiences (p = 0.001) and would like to involve their co-students in scholarly research activities (p = 0.002); whereas the majority of the medical students desired to be involved more in scholarly research publications (p = 0.033). Conclusion: Pharmacy students had good attitudes towards research activities and a higher number of medical students desired to be involved more in research publications. Faculties may consider taking special research initiatives to address the barriers and improve the involvement of medical and pharmacy students in scholarly research activities.
    Country participated: Asia (Malaysia, India, Saudi Arabia and the United Arab Emirates) and African (Ethiopia, Kenya and Egypt)
    Matched MeSH terms: Research*
  18. Ng KH, Peh WC
    Singapore Med J, 2009 Mar;50(3):245-9.
    PMID: 19352565
    Illustrations (also known as figures) are visual representations of the results obtained from a scientific study. Graphs are a common type of illustration that are often used in scientific papers to present information clearly and effectively, as well as to demonstrate relationships between variables in the data. Graphs also serve to reveal trends or patterns in the data. This article provides some basic guidelines to assist authors in preparing effective graphs for their papers.
    Matched MeSH terms: Biomedical Research*
  19. SANDOSHAM AA, BENNETT GF, FONG YL, OMAR EI
    Singapore Med J, 1965 Mar;6(1):47-8.
    PMID: 14306412
    An immature Glossy Tree-Starling (Aplonis panayensis strigatus), also known as ‘burong perling’ in Malay, was captured in the vicinity of the Institute for Medical Research, Kuala Lumpur. It was found to harbour a small malaria parasite which showed the characteristics of the sub-genus Novyella (Corradetti et al, 1963) viz:
    1. Trophozoites small with little cytoplasm, relatively large nuclear elements, the parasite usually applied to the host-cell nucleus.
    2. Schizonts with usually less than eight merozoites. 3. Pigment small and difficult to see except in the schizonts and in the gametocytes where the pigment granules are large and usually clustered at one end.
    4. The parasite rarely distorts the host erythrocyte. Unfortunately the bird died a few days later before detailed work on duration of the schizogonic cycle and experimental transmission could be done. The parasite has the following morphological features and most of the larger forms, asexual and sexual, assume the characteristic position proximal to the nucleus of the avian erythrocyte. Trophozoites: The earliest forms are ‘rings’ with a fairly marked vacuole. As the organism grows older, it produces a grain or two of pigment. The parasite at this stage tends to occupy a polar position in the host erythrocyte. Schizonts: The segmenting forms are usually attached to the pole end of the host-cell nucleus. The number of chromatin segments varies from 3 to 8, with a prevalent range of 4 to 6. The cytoplasm is scanty and pale with a prominent little mass of blackish-brown pigment or a close collection of granules. A rare mature schizont with 8 merozoites was seen in which the nucleus of the parasitised erythrocyte was displaced somewhat similar to figure 20 of Plate I portrayed in the original paper by Manwell (1935). Gametocytes: The sexual forms are often narrow and elongate, and are closely applied to the nucleus of the host erythrocyte. The outline of the parasite is frequently irregular. The cytoplasm is pale and vacuolated with coarse conspicuous granules of blackish-brown pigment usually collected at one end; sometimes either one or both ends curved around the host-cell nucleus. Although this parasite has some affinites to both P. nucleophiltim and P. hexamerium the lack of adequate study of the avian malarias of South-East Asia precludes even provisional identification of this parasite. On two occasions numerous gametocytes were seen in the peripheral blood of the bird and four species of laboratory-reared culicines (three indigenous to Malaya) were allowed to feed on it. Ten Andes togoi, 19 Culex sitiens and seven Culex fatigans were completely refractory to development of the parasite. Two of 17 Aedes aegypti had a single small oocyst each; both oocysts appeared to be degenerating. A Giemsa-stained thin blood film together with drawings made from the microscope showing the different forms of the parasite were demonstrated. REFERENCES
    Corradetti, A., Garnham, P. C. & Laird, M. (i963). Parassitologia, 5, 1-4.
    Manwell, R. D. (l935). Amer. J. Trop. Med 15, 265-283.
    ...(1938). Ibid., 18, 565-575
    Matched MeSH terms: Research*
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