MyMedR

Fulltext National Institutes of Health (NIH) Guidelines for Conducting Research in Ministry of Health (MOH) Institutions and Facilities, Third Edition

Citation: National Institutes of Health (NIH) Guidelines for Conducting Research in Ministry of Health (MOH) Institutions and Facilities, Third Edition. Putrajaya: Ministry of Health, Malaysia; 2021

Matched MeSH terms: Research

Fulltext Nutrition Research Priorities in Malaysia - For 12th Malaysia Plan (2021-2025)

ISBN: 978-967-19598-0-0

Citation: National Coordinating Committee on Food and Nutrition. Nutrition Research Priorities in Malaysia - For 12th Malaysia Plan (2021-2025). Putrajaya: Ministry of Health Malaysia, 2020

Older versions:
National Coordinating Committee on Food and Nutrition. Nutrition Research Priorities in Malaysia - For 10th Malaysia Plan (2011-2015). Putrajaya: Ministry of Health Malaysia, 2009
National Coordinating Committee on Food and Nutrition. Nutrition Research Priorities in Malaysia - For 11th Malaysia Plan (2016-2020). Putrajaya: Ministry of Health Malaysia, 2020

Matched MeSH terms: Research

Editorial: Inclusion, equity, diversity and social justice in movement disorders research

Miyasaki JM, Lim TT, Bhidayasiri R

Parkinsonism Relat Disord, 2021 04;85:114-116.

PMID: 33840573 DOI: 10.1016/j.parkreldis.2021.03.022

Matched MeSH terms: Research Personnel*; Biomedical Research*

Case series of COVID-19 with spontaneous pneumomediastinum

Nur Munirah I, Chidambaram SK

Med J Malaysia, 2022 01;77(1):92-94.

PMID: 35087002

Spontaneous pneumomediastinum is a rare condition in viral pneumonia. However, it can arise spontaneously in COVID-19 patients with no other risk factors. Here we present four cases of spontaneous pneumomediastinum in patients with COVID-19 pneumonia with no other precipitating factors.

Matched MeSH terms: Research

Fulltext Deriving partial differential equation for the value of Salam contract with credit risk

Hisham, A.F.B., Jaffar, M.M., Othman, J.

Pertanika Journal of Science & Technology, 2017;25(3):775-786.

MyJurnal

There are many research papers on implementing the salam structure in the financial system. This
study introduces a mathematical model of salam contract with credit risk that can be used as an Islamic financial derivative. It explores the properties of salam contract and the credit model that represents it, that is, the structural model with the default event on maturity of the salam contract.

Matched MeSH terms: Research

Factors affecting adherence to behaviours appropriate for the prevention of pressure injuries in people with spinal cord injury from Malaysia: a qualitative study

Mohamad Hashim N, Yusof ANM, Engkasan JP, Hasnan N

Spinal Cord, 2021 Jul;59(7):777-786.

PMID: 33230272 DOI: 10.1038/s41393-020-00586-1

STUDY DESIGN: Focus group qualitative study.

OBJECTIVES: To explore factors affecting adherence to behaviours appropriate for the prevention of pressure injuries (PIs) in people with spinal cord injury (SCI) in Malaysia.

SETTING: University Hospital, Malaysia METHODS: Four sets of focus group interviews were conducted, each with 5-10 participants, totalling 30 people with SCI. A trained interviewer used structured interviews designed to explore participants' experiences of complying with recommended behaviours for the prevention of PIs. All interviews were digitally recorded, transcribed, and analysed utilising thematic analysis.

RESULTS: The factors that affected participants' adherence are classified into four main themes: (a) educational aspects, (b) internal drive, (c) social and environmental factors, and (d) post-SCI physiological changes.

CONCLUSIONS: This qualitative study provides initial exploratory evidence regarding the thoughts, experience, and opinions pertaining to PI preventive behaviours within the Malaysian SCI population. The emerging themes contribute to an in-depth understanding of the competency of the Malaysian healthcare system in PI prevention, personal and societal factors influenced by the socio-demographic backgrounds, and disease-related factors that influence the adherence to such preventive interventions.

Matched MeSH terms: Qualitative Research

Process optimisation of defatted wheat germ protein extraction in a novel alkaline-based deep eutectic solvent (DES) via Box-Behnken experimental design (BBD)

Olalere OA, Gan CY

Food Chem, 2023 May 30;409:135224.

PMID: 36577323 DOI: 10.1016/j.foodchem.2022.135224

This is the first study to provide a preliminary investigation into the recovery of protein from wheat germ and the prediction of their extraction conditions in microwave cavity using a novel DES solvent. The response surface methodology was used to predict the microwaved protein extraction conditions of the DWG. The effects of DES buffer-concentration (X1: 0.01-1.00 g/mL), microwave power (X2: 50-250 W), irradiation time (X3: 1-5 min) and sample-to-buffer ratio (X4: 1:10-1:50) were tested using a single factor and Box-Behnken experimental design. Under the optimized conditions (X1 = 0.52 g/mL, X2 = 186 W, X3 = 3.28 min, and X4 = 1:39) protein yield and absorbed microwave were obtained at the optimal value of 33.00 % and 677 J/min, respectively with no denaturation of the protein as validated from the SDS-PAGE gel electrophoresis profile. Consequently, this investigation provides a practical approach for the extraction of bioactive protein from DWG using a novel deep eutectic solvent.

Matched MeSH terms: Research Design

Understanding Clinical Significance in Rehabilitation: A Primer for Researchers and Clinicians

Armijo-Olivo S, de Castro-Carletti EM, Calixtre LB, de Oliveira-Souza AIS, Mohamad N, Fuentes J

Am J Phys Med Rehabil, 2022 Jan 01;101(1):64-77.

PMID: 34091470 DOI: 10.1097/PHM.0000000000001799

The objective of this review was to summarize the concept of clinical significance and associated methods focusing on the area of rehabilitation to provide a resource to rehabilitation researchers and clinicians. Studies were searched on electronic databases from inception until July 28, 2020, with no date or language limits. Manual searches as well as Scopus forward citation for relevant references were performed. Narrative synthesis of study results was performed. Definitions of the concepts related to clinical significance, ways of calculating, and interpreting each method were provided using rehabilitation examples. An explanation of methods to evaluate clinical significance (distribution, anchor, and opinion-based methods) and their advantages and disadvantages were also provided. Considering the limitations of statistical significance in assuring meaningfulness of results, clinical interpretation of research outcomes and the report of clinical significance in intervention trials should be a priority in rehabilitation research. When possible, the use of multiple methods (distribution, anchor, and opinion based) is recommended. Thus, clinical researchers are encouraged to present results in a manner that allow the rehabilitation professionals to easily interpret and implement those results in their clinical practice.

Matched MeSH terms: Rehabilitation Research*; Research Design; Research Personnel

Fulltext Application of Bayesian structural equation modeling in construction and demolition waste management studies: Development of an extended theory of planned behavior

Mohamed NA, Alanzi ARA, Azizan AN, Azizan SA, Samsudin N, Salarzadeh Jenatabadi H

PLoS One, 2024;19(1):e0290376.

PMID: 38261595 DOI: 10.1371/journal.pone.0290376

Sustainable construction and demolition waste management relies heavily on the attitudes and actions of its constituents; nevertheless, deep analysis for introducing the best estimator is rarely attained. The main objective of this study is to perform a comparison analysis among different approaches of Structural Equation Modeling (SEM) in Construction and Demolition Waste Management (C&DWM) modeling based on an Extended Theory of Planned Behaviour (Extended TPB). The introduced research model includes twelve latent variables, six independent variables, one mediator, three control variables, and one dependent variable. Maximum likelihood (ML), partial least square (PLS), and Bayesian estimators were considered in this study. The output of SEM with the Bayesian estimator was 85.8%, and among effectiveness of six main variables on C&DWM Behavioral (Depenmalaydent variables), five of them have significant relations. Meanwhile, the variation based on SEM with ML estimator was equal to 78.2%, and four correlations with dependent variable have significant relationship. At the conclusion, the R-square of SEM with the PLS estimator was equivalent to 73.4% and three correlations with the dependent variable had significant relationships. At the same time, the values of the three statistical indices include root mean square error (RMSE), mean absolute percentage error (MPE), and mean absolute error (MSE) with involving Bayesian estimator are lower than both ML and PLS estimators. Therefore, compared to both PLS and ML, the predicted values of the Bayesian estimator are closer to the observed values. The lower values of MPE, RMSE, and MSE and the higher values of R-square will generate better goodness of fit for SEM with a Bayesian estimator. Moreover, the SEM with a Bayesian estimator revealed better data fit than both the PLS and ML estimators. The pattern shows that the relationship between research variables can change with different estimators. Hence, researchers using the SEM technique must carefully consider the primary estimator for their data analysis. The precaution is necessary because higher error means different regression coefficients in the research model.

Matched MeSH terms: Research Personnel

Fulltext Control and switching synchronization of fractional order chaotic systems using active control technique

Radwan AG, Moaddy K, Salama KN, Momani S, Hashim I

J Adv Res, 2014 Jan;5(1):125-32.

PMID: 25685479 DOI: 10.1016/j.jare.2013.01.003

This paper discusses the continuous effect of the fractional order parameter of the Lü system where the system response starts stable, passing by chaotic behavior then reaching periodic response as the fractional-order increases. In addition, this paper presents the concept of synchronization of different fractional order chaotic systems using active control technique. Four different synchronization cases are introduced based on the switching parameters. Also, the static and dynamic synchronizations can be obtained when the switching parameters are functions of time. The nonstandard finite difference method is used for the numerical solution of the fractional order master and slave systems. Many numeric simulations are presented to validate the concept for different fractional order parameters.

Matched MeSH terms: Research Design

Fulltext Cell targeting in anti-cancer gene therapy

Lila MA, Siew JS, Zakaria H, Saad SM, Ni LS, Abdullah JM

Malays J Med Sci, 2004 Jan;11(1):9-23.

PMID: 22977356 MyJurnal

Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to improve cellular uptake efficiency of gene-based therapies. This paper highlights advancements in gene therapy research and its application in relation to anti-cancer treatment.

Matched MeSH terms: Genetic Research

Fulltext Is research related to a country's economic development? An analysis of biomedical publications from several GCC and ASEAN countries from 1994-2013

Tang CT, Wilkerson PM, Soon Y

Med J Malaysia, 2016 04;71(2):57-61.

PMID: 27326942

INTRODUCTION: Biomedical research has traditionally been the domain of developed countries. We aim to study the effects of the increased focus on biomedical and medical research on level 1-4 publications in several industrialised and newly industrialised countries endowed with petroleum and gas resources.

METHODS: We identified all level 1-4 publications from 01/01/1994 to 31/12/2013 via PubMed using advanced options. The population and GDP (current US$) data from 1994-2013 were obtained through data provided by the World Bank and the raw data was normalised based on these two indicators.

RESULTS: From 1994-2013, Saudi Arabia and Malaysia were responsible for the highest absolute number of level 1 to 4 biomedical and medical research publications with 2551 and 1951 publications respectively. When normalised to population, Kuwait and Qatar had the highest publication rates, with 7.84 and 3.99 publications per 100,000 inhabitants respectively in a five yearly average. Kuwait produced the largest number of publications per billion (current US$) of GDP, at 2.92 publications, followed by Malaysia at 2.82 publications in a five yearly average.

CONCLUSION: The population size of a country as well as GDP can influence the number of level 1-4 publications in some countries. More importantly, effective government policy which stimulates research as well as a culture which actively promotes research as shown by Malaysia have proven to have a larger influence on the amount of level 1-4 biomedical and medical publications.

Matched MeSH terms: Biomedical Research*

Fulltext The National Medical Research Register--a vital link between current and future research

Lim TO, Asmaliza SI, Goh PP, Michael AJ, Hon YK, Thandapani R, et al.

Med J Malaysia, 2010 Jun;65 Suppl A:124-7.

PMID: 21488472

Registration of research proposal to a publicly accessible website with searchable function allows information sharing and ensures research transparency. The National Institutes of Health Malaysia, realising the importance of research registration, established the National Medical Research Register (NMRR) in 2007. The NMRR functions more than just a local register: it also links to ethics approval and MOH medical research grant application. It thus facilitates researchers in their application to the Ministry of Health Research and Ethics Committee (MREC) and for Ministry of Health research grant. In addition, MREC committee members can review research protocol on NMRR website, thus saving much time and resources. From May 2007 till December 2009, more than 3000 people have registered as NMRR public users and more than 1000 research proposals have been uploaded in NMRR. The number of registration of research proposals, clinical trials and industrial sponsored trials steadily increased from year 2007 to year 2009. The web-based NMRR is the first research register in the world that links research proposal registration to ethical review and research grant application. Its future plan is to be linked with publication. Therefore, it is indeed an innovation that Malaysians should be proud of.

Matched MeSH terms: Biomedical Research*

Making it real: a hands-on approach to teaching research

Birks M

Int Nurs Rev, 2011 Jun;58(2):270-2.

PMID: 21554303 DOI: 10.1111/j.1466-7657.2011.00894.x

The purpose of this paper was to report on the delivery of a series of seminars in Sarawak, East Malaysia using a unique hands-on approach to the teaching of skills in research and evidence-based health care. These seminars proved to be a meaningful and memorable experience for both the facilitators and participants.

Matched MeSH terms: Biomedical Research/education*

Fulltext Behaviour Change in Public Health: Evidence and Implications

Pokhrel S, Anokye NK, Reidpath DD, Allotey P

Biomed Res Int, 2015;2015:598672.

PMID: 26380284 DOI: 10.1155/2015/598672

Matched MeSH terms: Biomedical Research*

Fulltext Giant Magnetoresistance Sensors: A Review on Structures and Non-Destructive Eddy Current Testing Applications

Rifai D, Abdalla AN, Ali K, Razali R

Sensors (Basel), 2016;16(3):298.

PMID: 26927123 DOI: 10.3390/s16030298

Non-destructive eddy current testing (ECT) is widely used to examine structural defects in ferromagnetic pipe in the oil and gas industry. Implementation of giant magnetoresistance (GMR) sensors as magnetic field sensors to detect the changes of magnetic field continuity have increased the sensitivity of eddy current techniques in detecting the material defect profile. However, not many researchers have described in detail the structure and issues of GMR sensors and their application in eddy current techniques for nondestructive testing. This paper will describe the implementation of GMR sensors in non-destructive testing eddy current testing. The first part of this paper will describe the structure and principles of GMR sensors. The second part outlines the principles and types of eddy current testing probe that have been studied and developed by previous researchers. The influence of various parameters on the GMR measurement and a factor affecting in eddy current testing will be described in detail in the third part of this paper. Finally, this paper will discuss the limitations of coil probe and compensation techniques that researchers have applied in eddy current testing probes. A comprehensive review of previous studies on the application of GMR sensors in non-destructive eddy current testing also be given at the end of this paper.

Matched MeSH terms: Research; Research Personnel

Research misconduct

Khalid BA

Med J Malaysia, 2000 Aug;55 Suppl B:14-6.

PMID: 11125514

Matched MeSH terms: Research*

Research training as pillars towards undergraduate medical education advancement in Malaysia

Rampal L

Med J Malaysia, 2002 Dec;57 Suppl E:102-4.

PMID: 12733203

Matched MeSH terms: Research/education*

Confidentiality in research