Displaying publications 201 - 220 of 6270 in total

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  1. Simultaneous non-Hodgkin lymphoma of the external auditory canal and thyroid gland: A case report
    Khaw B, Sivalingam S, Pathamanathan SS, Tan TS, Naicker M
    Ear Nose Throat J, 2014 12;93(12):508-11.
    PMID: 25531844
    Approximately 25% of all cases of extranodal non-Hodgkin lymphoma (NHL) occur in the head and neck region; NHL of the external auditory canal (EAC) and thyroid gland are rare. Specific immunohistochemical staining of the excised tissue is required to confirm the final pathologic diagnosis. We report the case of a 53-year-old woman with underlying systemic lupus erythematosus and autoimmune hemolytic anemia that were in remission. She presented with chronic left ear pain, a mass in the left EAC, and rapid growth of an anterior neck swelling that had led to left vocal fold palsy. High-resolution computed tomography (CT) of the temporal bone and CT of the neck detected a mass lateral to the left tympanic membrane and another mass in the anterior neck that had infiltrated the thyroid gland. The patient was diagnosed with simultaneous B-cell lymphoma of the left EAC and thyroid gland. She was treated with chemotherapy. She responded well to treatment and was lost to follow-up after 1 year. To the best of our knowledge, the simultaneous occurrence of a lymphoma in the EAC and the thyroid has not been previously described in the literature.
    Matched MeSH terms: Ear Neoplasms/diagnosis*; Ear Neoplasms/therapy; Neoplasms, Multiple Primary/diagnosis*; Neoplasms, Multiple Primary/therapy; Thyroid Neoplasms/diagnosis*; Thyroid Neoplasms/therapy
  2. Self-perceived burden and its associations with health-related quality of life among urologic cancer patients
    Ting CY, Teh GC, Yu KL, Alias H, Tan HM, Wong LP
    Eur J Cancer Care (Engl), 2020 Jul;29(4):e13248.
    PMID: 32495472 DOI: 10.1111/ecc.13248
    OBJECTIVE: This study examined the prevalence of self-perceived burden (SPB) and its association with health-related quality of life (HRQoL) among urologic cancer patients.

    METHODS: This was a prospective, cross-sectional study. A total of 429 respondents diagnosed with urologic cancers (prostate, bladder and renal cancer) from Sarawak General Hospital and Subang Jaya Medical Centre in Malaysia were interviewed by using a structured questionnaire. SPB and HRQoL were measured by the Self-perceived Burden Scale and the Functional Assessment of Cancer Therapy-General 7 Item Scale respectively.

    RESULTS AND CONCLUSION: Self-perceived burden was experienced by 73.2% of the respondents. Respondents who had a lower education level, a monthly household income

    Matched MeSH terms: Urinary Bladder Neoplasms/physiopathology; Urinary Bladder Neoplasms/psychology*; Kidney Neoplasms/physiopathology; Kidney Neoplasms/psychology*; Prostatic Neoplasms/physiopathology; Prostatic Neoplasms/psychology*
  3. Fulltext Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium
    Ordóñez-Mena JM, Schöttker B, Mons U, Jenab M, Freisling H, Bueno-de-Mesquita B, et al.
    BMC Med, 2016;14(1):62.
    PMID: 27044418 DOI: 10.1186/s12916-016-0607-5
    BACKGROUND: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality.
    METHODS: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs.
    RESULTS: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking.
    CONCLUSIONS: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.
    KEYWORDS: Cancer; Cohort; Incidence; Meta-analysis; Mortality; Smoking
    Matched MeSH terms: Breast Neoplasms/epidemiology*; Breast Neoplasms/prevention & control; Lung Neoplasms/epidemiology*; Lung Neoplasms/prevention & control; Prostatic Neoplasms/epidemiology*; Prostatic Neoplasms/prevention & control
  4. Postmastectomy radiotherapy in patients with breast cancer
    Bhoo-Pathy N, Pignol JP, Verkooijen HM
    Lancet, 2014 Nov 22;384(9957):1846.
    PMID: 25457914 DOI: 10.1016/S0140-6736(14)62239-X
    Matched MeSH terms: Breast Neoplasms/mortality*; Breast Neoplasms/radiotherapy*
  5. Skeletal-related events among breast and prostate cancer patients: towards new treatment initiation in Malaysia's hospital setting
    Ezat SW, Syed Junid SM, Noraziani K, Zafar A, Saperi S, Nur AM, et al.
    Asian Pac J Cancer Prev, 2013;14(5):3357-62.
    PMID: 23803129
    The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases are a major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostate whereas breast cancer is among those in females, both being associated with skeletal lesions. Bone metastases weaken bone structure, causing a range of symptoms and complications thus developing skeletal-related events (SRE). Patients with SRE may require palliative radiotherapy or surgery to bone for pain, having hypercalcaemia, pathologic fractures, and spinal cord compression. These complications contribute to a decline in patient health- related quality of life. The multidimensional assessment of health-related quality of life for those patients is important other than considering a beneficial treatment impact on patient survival, since the side effects of treatment and disease symptoms can significantly impact health-related quality of life. Cancer treatment could contribute to significant financial implications for the healthcare system. Therefore, it is essential to assess the health-related quality of life and treatment cost, among prostate and breast cancer patients in countries like Malaysia to rationalized cost-effective way for budget allocation or utilization of health care resources, hence helping in providing more personalized treatment for cancer patients.
    Matched MeSH terms: Bone Neoplasms/economics*; Bone Neoplasms/secondary*; Bone Neoplasms/therapy; Breast Neoplasms/economics; Breast Neoplasms/pathology*; Breast Neoplasms/therapy; Prostatic Neoplasms/economics; Prostatic Neoplasms/pathology*; Prostatic Neoplasms/therapy
  6. Fulltext Delay in diagnosis of upper gastrointestinal cancer: whose fault is it?
    Tata MD, Dharmendran R, Ramesh G, Kandasami P
    Med J Malaysia, 2013 Jun;68(3):275-7.
    PMID: 23749025 MyJurnal
    Stomach and esophageal cancers are both deadly and difficult to diagnose early. Stomach cancer is the second most common cancer in Asia. Both these are one of the most common causes of cancer related death in the world.
    Matched MeSH terms: Esophageal Neoplasms*; Stomach Neoplasms
  7. Fulltext Triple primary cancers of the larynx, lung and thyroid presenting in one patient
    Iqbal FR, Sani A, Gendeh BS, Aireen I
    Med J Malaysia, 2008 Dec;63(5):417-8.
    PMID: 19803306 MyJurnal
    Patients with multiple malignant primary tumours are often described, based on their chronology of presentation, as simultaneous, synchronous or metachronous tumours. Lung malignancies presenting in association with head and neck tumours are well documented while there have been small series of thyroid synchronous cancers presenting with laryngeal lesions in literature. No cases, to our knowledge, have been reported in literature of a single patient with all three laryngeal, lung and thyroid malignancies. We report one such case of a 71-year-old Chinese man who had undergone a total laryngectomy for a recurrent cancer of the larynx only to be found to have tumours of the lung and thyroid in the post-operative period and he eventually died of post-operative complications. We also discuss screening for lung and thyroid malignancies in patients with head and neck squamous cell carcinoma (SCC).
    Matched MeSH terms: Laryngeal Neoplasms/diagnosis*; Laryngeal Neoplasms/surgery; Lung Neoplasms/diagnosis*; Lung Neoplasms/surgery; Neoplasms, Multiple Primary/diagnosis*; Neoplasms, Multiple Primary/surgery; Thyroid Neoplasms/diagnosis*; Thyroid Neoplasms/surgery
  8. Fulltext Extra-adrenal paraganglioma: presentation in three uncommon locations
    Mun KS, Pailoor J, Chan KS, Pillay B
    Malays J Pathol, 2009 Jun;31(1):57-61.
    PMID: 19694315 MyJurnal
    Extra-adrenal paragangliomata are uncommon entities. They can be classified into four basic groups according to their anatomical sites, i.e. branchiomeric, intravagal, aorticosympathetic and visceral autonomic. Similar tumours may arise in sites away from the usual distribution of the sympathetic and parasympathetic ganglia, e.g. orbit, nose, small intestine and even in the pancreas. We report three instructive cases of extra-adrenal paraganglioma which were found in unusual sites such as urinary bladder, thyroid gland and on the wall of the inferior vena cava.
    Matched MeSH terms: Urinary Bladder Neoplasms/metabolism; Urinary Bladder Neoplasms/pathology*; Urinary Bladder Neoplasms/surgery; Thyroid Neoplasms/metabolism; Thyroid Neoplasms/pathology*; Thyroid Neoplasms/surgery; Vascular Neoplasms/metabolism; Vascular Neoplasms/pathology*; Vascular Neoplasms/surgery
  9. Fulltext Surgical management of a massive facial hemangioma
    Baharudin A, Samsudin AR, Halim AS, Shafie MA
    Med J Malaysia, 2007 Aug;62(3):254-5.
    PMID: 18246921 MyJurnal
    Hemangiomas are the most common congenital lesions in man and occur predominantly in the head and neck region. Massive hemangioma especially near vital organs or structures pose a challenge to surgeons. With the availability of expertise in embolization of feeding vessel of the hemangioma and reconstructive techniques we were able to manage successfully a complicated case of massive facial hemangioma.
    Matched MeSH terms: Facial Neoplasms/pathology; Facial Neoplasms/surgery*
  10. Lectin-based electrophoretic analysis of the expression of the 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies
    Mohamed E, Abdul-Rahman PS, Doustjalali SR, Chen Y, Lim BK, Omar SZ, et al.
    Electrophoresis, 2008 Jun;29(12):2645-50.
    PMID: 18494030 DOI: 10.1002/elps.200700828
    A 35 kDa glycoprotein whose abundance was previously demonstrated to be enhanced in sera of patients with endometrial adenocarcinoma (n = 12), was isolated from pooled sera of three of the cancer patients using champedak galactose-binding lectin affinity chromatography in the present study. Subjecting it to 2-DE and MS/MS, the glycoprotein was identified as the O-glycosylated fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4). When compared to control sera (n = 17), expression of the 35 kDa ITIH4 cleavage fragment was demonstrated to be significantly enhanced in sera of patients with breast carcinoma (n = 10), epithelial ovarian carcinoma (n = 10), and germ cell ovarian carcinoma (n = 10) but not in patients with nasopharyngeal carcinoma (n = 13) and osteosarcoma (n = 7). The lectin-based electrophoretic bioanalytical method adopted in the present study may be used to assess the physiological relevance of ITIH4 fragmentation and its correlation with different malignancies, their stages and progression.
    Matched MeSH terms: Bone Neoplasms/metabolism; Breast Neoplasms/metabolism; Nasopharyngeal Neoplasms/metabolism; Neoplasms, Germ Cell and Embryonal/metabolism; Neoplasms, Glandular and Epithelial/metabolism; Ovarian Neoplasms/metabolism
  11. Orbital rhabdomyosarcoma in an HIV positive child
    Khairy-Shamel ST, Shatriah I, Adil H, Zunaina E, Bakiah S, Rohaizan Y, et al.
    Orbit, 2008;27(5):388-90.
    PMID: 18836940 DOI: 10.1080/01676830802336629
    We reported a case of orbital rhabdomyosarcoma with an intracranial extension in an HIV-infected child. It was an uncommon sarcoma in a retroviral-positive patient that resulted in a diagnostic and therapeutic dilemma. The child is currently asymptomatic following surgery, chemotherapy, and reinstitution of highly active retroviral therapy (HAART).
    Matched MeSH terms: Brain Neoplasms/pathology*; Brain Neoplasms/radiography; Brain Neoplasms/surgery; Orbital Neoplasms/pathology*; Orbital Neoplasms/radiography; Orbital Neoplasms/surgery; Paranasal Sinus Neoplasms/pathology*; Paranasal Sinus Neoplasms/radiography; Paranasal Sinus Neoplasms/surgery
  12. Fulltext Primary Burkitt lymphoma of the ovary
    Ng SP, Leong CF, Nurismah MI, Shahila T, Jamil MA
    Med J Malaysia, 2006 Aug;61(3):363-5.
    PMID: 17240592 MyJurnal
    A 20 year-old woman presented with features of a twisted ovarian cyst and had an emergency laparotomy Intraoperative findings revealed bilateral, solid ovarian tumors and a left oophorectomy with biopsy of the contralateral ovary performed. Histopathology report confirmed Burkitt lymphoma of ovary. There was no other evidence of lymphoma elsewhere. The primary Burkitt lymphoma of the ovaries was successfully managed with six courses of highly toxic chemotherapy (Berlin-Frankfurt- Munster 1986 protocol). The patient has remained disease free for the last 36 months.
    Matched MeSH terms: Ovarian Neoplasms/pathology*; Ovarian Neoplasms/surgery
  13. Fulltext Epidemiology of breast cancer in Malaysia
    Yip CH, Taib NA, Mohamed I
    Asian Pac J Cancer Prev, 2006;7(3):369-74.
    PMID: 17059323
    Data from the National Cancer Registry of Malaysia for 2004 provide an age-standardised incidence rate (ASR) of 46.2 per 100,000 women. This means that approximately 1 in 20 women in the country develop breast cancer in their lifetime. However, the rate differs between the three main races, the Malays, Chinese and Indians. The age standardized incidence in Chinese is the highest, with 59.7 per 100,000, followed by the Indians at 55.8 per 100,000. The Malays have the lowest incidence of 33.9 per 100,000. This translates into 1 in 16 Chinese, 1 in 16 Indian and 1 in 28 Malay women developing breast cancer at some stage in their lives. The commonest age at presentation is between 40-49 years, with just over 50% of the cases under the age of 50 years, 16.8% below 40, and 2% under 30. Some 55.7% of all cases were found to be ER positive. The commonest presenting symptom was a lump in the breast in over 90% of cases, generally felt by the woman herself. The mean size of the lump was 4.2 cm, and on average, the women waited 3 months before seeking medical attention. Over the 12-year period from 1993 to 2004, about 60-70% of women presented with early stage (Stages 1-2) while 30-40% presented with late breast cancer (Stages 3-4). Especially Malays present at later stages and with larger tumours. Consequently their survival is worse than with Chinese and Indian women. The challenge in Malaysia is to be able to provide a comprehensive service in the diagnosis and treatment of breast cancer, and this requires training of a team of health professionals dedicated to breast health, such as breast surgeons, radiologists specializing in breast imaging, breast pathologists, plastic surgeons specializing in breast reconstruction, medical and radiation oncologists, psycho-oncologists, counselors, and breast nurses. Advocacy can play a role here in galvanizing the political will to meet this challenge.
    Matched MeSH terms: Breast Neoplasms/diagnosis; Breast Neoplasms/epidemiology*
  14. An interesting case of isolated pancreatic teratoma: lessons to learn
    Razman J, Azlanudin A, Eyad AJ, Zahiah M, Das S
    Clin Ter, 2012 Nov;163(6):495-7.
    PMID: 23306744
    Mature cystic teratomas of the pancreas are extremely rare tumours encountered in day-to-day clinical practice. Only few cases have been reported to date involving all age groups. The management, diagnosis and evaluation of this tumor are questionable, with definitive diagnosis taking place intra-operatively. We hereby report the case in a 30 year-old-male who presented with newly diagnosed diabetes mellitus and during the follow up he was noted to have elevated liver enzymes clinically, he was asymptomatic. The computerized tomography revealed a retropancreatic mass and pushing the mesenteric veins anteriorly. The mass was hypodense in nature and there was presence of calcification. Although the patient was asymptomatic, the decision for resecting the mass was made in view of the size and possibility of malignancy. In conclusion, considering the size and approximity of the mass to the pancreas, Whipple procedure's is the most appropriate approach although the histological diagnosis has not been established preoperatively.
    Matched MeSH terms: Pancreatic Neoplasms/pathology*; Pancreatic Neoplasms/surgery
  15. Fulltext Nasal cylindrical cell papilloma
    Subha ST, Prepageran N
    Med J Malaysia, 2005 Mar;60(1):103-5.
    PMID: 16250292
    Inverted papilloma is the most common benign tumor of nose and paranasal sinuses arising from lateral nasal wall and middle meatus. Histologically these tumors are composed of epithelial nests that are inverted, exophytic and cylindrical. Here we describe a clinical case of nasal cylindrical cell papilloma, which was treated by endoscopic excision.
    Matched MeSH terms: Nose Neoplasms/diagnosis*; Nose Neoplasms/surgery*
  16. Clinical usefulness of tumour markers
    Lai LC, Cheong SK, Goh KL, Leong CF, Loh CS, Lopez JB, et al.
    Malays J Pathol, 2003 Dec;25(2):83-105.
    PMID: 16196365
    Tumour markers are substances related to the presence or progress of a tumour. An ideal tumour marker is (1) detectable only when malignancy is present, (2) specific for the type and site of malignancy, (3) correlates with the amount of malignant tissue present and (4) responds rapidly to a change in tumour size. At present, no tumour marker fulfills all of the above criteria. The first part of the review discusses the clinical usefulness of the commonly requested serum tumour markers, namely, prostate-specific antigen (PSA), CA 19-9, carcinoembryonic antigen (CEA), CA 125, CA 15-3, human chorionic gonadotrophin (hCG) and alpha-foetoprotein (AFP). It is hoped that this review article will decrease the abuse and misuse of these commonly requested serum tumour markers. The second part of the review discusses the clinical usefulness of catecholamines and their metabolites, calcitonin, thyroglobulin, parathyroid hormone, prolactin, adrenocorticotrophic hormone, oestrogen and progesterone receptors, p53, HER-2/c-erbB2, BRCA1 and BRCA2.
    Matched MeSH terms: Neoplasms/diagnosis*; Neoplasms/metabolism
  17. Fulltext Prevalence of cancers of female organs among patients with diabetes type 2 in Kelantan, Malaysia: Observations over an 11 year period and strategies to reduce the incidence
    Jalil NA, Zin AA, Othman NH
    Asian Pac J Cancer Prev, 2015;16(16):7267-70.
    PMID: 26514522
    INTRODUCTION: Kelantan is one of the states in Malaysia which has a high prevalence of type 2 diabetes (DM2). Other than with endometrial carcinoma, the association of DM2 with particular female cancers is not known.
    OBJECTIVE: To determine the proportion of breast, cervical, ovarian and endometrial cancers among females with DM2 diagnosed in Hospital Universiti Sains Malaysia (HUSM) over an 11 year period.
    MATERIALS AND METHODS: All histologically confirmed cases of breast, endometrial, cervical and ovarian carcinomas admitted to the Hospital were included in the study. The patient diabetic status was traced from the hospital medical records.
    RESULTS: There was a total of 860 cases of breast, cervical, ovarian and endometrial carcinomas over this period. Breast carcinoma was the commonest, accounting for 437/860 (50.8%) followed by cervix, 159/860 (18.5%), ovarian, 143/860 (16.6%) and endometrial carcinomas, 121/860 (14.1%). Out of these, 228/860 (26.5%) were confirmed diabetics. Endometrial carcinoma patients showed the highest proportion being diabetics, 42.1% (51/121), followed by ovarian cancer, 25.9% (37/143), breast carcinoma, 23.6% (103/437) and cervical cancer 23.3% (37/159).
    CONCLUSIONS: There is a significant proportion of DM2 among women with these four cancers, endometrial carcinoma being the highest followed by ovarian, breast and cervical carcinoma. The rising trend of these four cancers is in tandem with an increasing trend of DM2 in the community. In populations where diabetes is prevalent, screening for epithelial cancers should be rigourous. Diabetic clinics should include screening for these cancers among their female patients and gynecology clinics should screen the women they treat for their diabetes status.
    Matched MeSH terms: Breast Neoplasms/etiology; Breast Neoplasms/epidemiology*; Uterine Cervical Neoplasms/etiology; Uterine Cervical Neoplasms/epidemiology*; Ovarian Neoplasms/etiology; Ovarian Neoplasms/epidemiology*; Endometrial Neoplasms/etiology; Endometrial Neoplasms/epidemiology*
  18. Fulltext Postauricular neurofibroma - a rare occurrence
    Shi Nee T, Ami M, Min Han K, Sabir Husin Athar PP
    Braz J Otorhinolaryngol, 2015 12 19;83(5):600-601.
    PMID: 26777080 DOI: 10.1016/j.bjorl.2015.09.001
    Matched MeSH terms: Ear Neoplasms/diagnosis*; Ear Neoplasms/surgery
  19. Fulltext Recent advances in the diagnosis and treatment of lung cancer
    Liam CK, Lim KH, Wong MM
    Med J Malaysia, 2001 Dec;56(4):514-31; quiz 532.
    PMID: 12014776
    Matched MeSH terms: Lung Neoplasms/diagnosis*; Lung Neoplasms/therapy*
  20. Mucoepidermoid carcinoma of the trachea (a case report)
    Said H, Phang KS, Gibb AG
    J Laryngol Otol, 1988 Jan;102(1):83-6.
    PMID: 3343572
    A case of mucoepidermoid carcinoma of the trachea in a 26-year-old female is presented. Diagnosis was confirmed by histopathology. On the basis of the clinical and histological picture, the tumour is classified as a low grade mucoepidermoid carcinoma. Conservative surgical treatment was the primary mode of treatment. The patient showed no clinical evidence of recurrence twelve months after local resection of the tumour.
    Matched MeSH terms: Tracheal Neoplasms/pathology*; Tracheal Neoplasms/surgery
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