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The evaluation of new psychoactive drugs

Müller CP, Hassan Z

Brain Res Bull, 2016 09;126(Pt 1):1-2.
PMID: 27235862 DOI: 10.1016/j.brainresbull.2016.05.013
Matched MeSH terms: Psychotropic Drugs/therapeutic use*
Fulltext The prescription of psychotropic medication in general practice--a descriptive study

Maniam T, Ting GS

Med J Malaysia, 1990 Sep;45(3):225-30.
PMID: 2152083

The prescriptions of all patients who attended an urban general practice from September 1987 to December 1987 were studied. Of the 111 patients (60 females and 51 males) who received a psychotropic prescription the commonest presenting complaint was insomnia (56 patients or 50.5%). This was followed by tension, headache and unexplained aches and pains (19 patients or 17.1%), and anxiety (nine patients or 8.1%). Consistent with these presentations a vast majority (92.8%) received a benzodiazepine. The commonest drugs prescribed were Lorazepam and Bromazepam whereas the longer acting benzodiazepines were rarely used. Polypharmacy was rare.

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
The international reference center for information on psychotropic drugs

Psychopharmacol Bull, 1977 Oct;13(4):8-48.
PMID: 905490
Matched MeSH terms: Psychotropic Drugs/therapeutic use*
The pattern of psychotropic drug usage in a general out-patient clinic

Yeoh OH

Med J Malaysia, 1979 Dec;34(2):167-70.
PMID: 548722

This study show that within a general hospital outpatient setting, the prescription of psychotropic medication is mainly confined to the anti-anxiety drugs and and secondarily to the hypnotics. There is a conspicuous absence of prescription for antipsychotic drugs and negligible use of antidepressants. The use of anti-anxiety drugs and hypnotics was higher in the general outpatient clinic than in the psychiatric outpatient clinic in the same hospital. This finding is in the trend of similar findings by others that non-psychiatrists prescribe more psychotropic medication including an-anxiety and hypnotic medication. In this study the use of psychotropic medication for patient generated psychiatric symptomalogy was only in 14.5% of cases prescribed these medication. The anti-anxiety drugs were prescribed as adjuncts in non-psychiatric conditions as well. Frequent use as adjuncts were in the treatment of muscular tension and in chronic cardiovascular disorders. There is a core of patients (20%) that had been continuously prescribed medication up to a period of 5 years. Half of these were chronic cardiovascular patients and half presented with no demonstrable systemic organicity. None had been referred to psychiatrist.
Study site: Outpatient clinic, general hospital, Malaysia

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
A comparison of clinical characteristics of older adults treated with antidepressants in general and psychiatric hospitals in Asia

Wang YY, Xiang YT, Ungvari GS, Ng CH, Chiu HFK, Yim LCL, et al.

Psychogeriatrics, 2017 Nov;17(6):348-355.
PMID: 28429844 DOI: 10.1111/psyg.12243

AIM: This study compared the demographics, clinical characteristics, and antidepressant prescription patterns between Asian patients aged 50 years and older attending psychiatric hospitals and those attending general hospitals.

METHODS: In total, 955 patients (604 in general hospitals, 351 in psychiatric hospitals) aged 50 years or older treated with antidepressants in 10 Asian countries and territories were examined. Patients' demographics, clinical features, and prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure.

RESULTS: Binary logistic regression revealed that high income and diagnosis of schizophrenia were independently associated with psychiatric hospital treatment, whereas outpatient care, diagnosis of anxiety disorders, and multiple major medical conditions were independently associated with general hospital treatment. In addition, tetracyclic and noradrenergic and specific serotonergic antidepressants were more likely to be prescribed in general hospitals.

CONCLUSION: Older adults treated with antidepressants showed different demographic and clinical features between general hospitals and psychiatric hospitals in Asia.

Study site: multi nation

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
Fulltext Mitragyna speciosa use in the northern states of Malaysia: a cross-sectional study

Ahmad K, Aziz Z

J Ethnopharmacol, 2012 May 7;141(1):446-50.
PMID: 22440259 DOI: 10.1016/j.jep.2012.03.009

ETHNOPHARMACOLOGICAL RELEVANCE:
The consumption of Mitragyna speciosa (MS) for its psychoactive effects is widely reported amongst people in the villages in Thailand and Malaysia even though its use is illegal.
AIM OF THE STUDY: This study examined the pattern of MS use, its reported effects and explored its potential to cause dependence.
MATERIALS AND METHODS: We used both convenience and snowball-sampling methods to recruit participants in a border town between two northern states in Malaysia. Face-to-face interviews were conducted with the use of a structured questionnaire on 562 respondents who gave oral consent to participate in the study.
RESULTS: The response rate was 91%. The majority of the respondents (88%) reported daily use of MS. The main mode of using MS was by drinking the MS extract as tea (90%). The mean age of starting MS use was 28.3 (SD=8.1) years. A variety of reasons were given for using MS including for social and recreational needs, stamina and physical endurance, pain relief and improved sexual performance. Despite its reported usefulness in weaning off opiate addiction, 460 (87%) admitted they were not able to stop using MS. Only education level had a statistically significant association with the ability to stop or not stop the use of MS (χ(2)=31.0, df=1, p<0.001). Significantly higher proportions of those with a lower education level (38%) were able to stop using MS compared to respondents with a higher education level.
CONCLUSIONS: Our study provides important information on the pattern of MS use, its effects and its potential to cause addiction, as there has been growing interest in MS as evidenced by the number of advertisements for its sale on the Internet. Future study is required to explore its psychological and social impact on users.

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
Comparison of psychotropic prescriptions between oncology and cardiology inpatients: result from a pharmacy database in a teaching hospital in Malaysia

Ng CG, Mohamed S, Wern TY, Haris A, Zainal NZ, Sulaiman AH

Asian Pac J Cancer Prev, 2014;15(10):4261-4.
PMID: 24935381

OBJECTIVE: To examine the prescription rates in cancer patients of three common psychotropic drugs: anxiolytic/ hypnotic, antidepressant and antipsychotic.
MATERIALS AND METHODS: In this retrospective cohort study, data were extracted from the pharmacy database of University Malaya Medical Center (UMMC) responsible for dispensing records of patients stored in the pharmacy's Medication Management and Use System (Ascribe). We analyzed the use of psychotropics in patients from the oncology ward and cardiology from 2008 to 2012. Odds ratios (ORs) were adjusted for age, gender and ethnicity.
RESULTS: A total of 3,345 oncology patients and 8,980 cardiology patients were included. Oncology patients were significantly more often prescribed psychotropic drugs (adjusted OR: anxiolytic/hypnotic=5.55 (CI: 4.64-6.63); antidepressants=6.08 (CI: 4.83-7.64) and antipsychotics=5.41 (CI: 4.17-7.02). Non-Malay female cancer patients were at significantly higher risk of anxiolytic/hypnotic use.
CONCLUSIONS: Psychotropic drugs prescription is common in cancer patients. Anxiolytic/hypnotic prescription rates are significantly higher in non-Malay female patients in Malaysia.

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
Are reports of cognitive testing among older electroconvulsive therapy recipients clinically valid?

Plakiotis C, Chin LF, O'Connor DW

J ECT, 2014 Mar;30(1):26-9.
PMID: 24487645 DOI: 10.1097/YCT.0000000000000082

Electroconvulsive therapy (ECT) administration rises in frequency with age, with older depressed adults often showing clinical features predictive of good response. Recent reviews suggest that older people experience few if any long-term cognitive adverse effects after contemporary ECT, despite their increased vulnerability to these. However, the broader clinical validity of research findings is not assured as most studies of ECT-related cognitive effects do not discuss cognitive test nonparticipants. This study examines whether cognitive test participants and nonparticipants are comparable.

Matched MeSH terms: Psychotropic Drugs/therapeutic use
Fulltext Psychiatric comorbidity among terminally ill patients in general practice in the Netherlands: a comparison between patients with cancer and heart failure

Ng CG, Dijkstra E, Smeets H, Boks MP, de Wit NJ

Br J Gen Pract, 2013 Jan;63(606):e63-8.
PMID: 23336475 DOI: 10.3399/bjgp13X660797

It is unclear whether psychiatric disorders are specifically related to the terminal phase of cancer, or independent of the underlying disease.

Matched MeSH terms: Psychotropic Drugs/therapeutic use*
Clinical and sociodemographic correlates of severe insomnia in psychotropic drug-free, Asian outpatients with major depressive disorder

Srisurapanont M, Likhitsathian S, Chua HC, Udomratn P, Chang S, Maneeton N, et al.

J Affect Disord, 2015 Nov 1;186:26-31.
PMID: 26226430 DOI: 10.1016/j.jad.2015.06.032

BACKGROUND: Little has been known regarding the correlates of severe insomnia in major depressive disorder (MDD). This post-hoc analysis aimed to examine the sociodemographic and clinical correlates of severe insomnia in psychotropic drug-free, Asian adult outpatients with MDD.
METHODS: Participants were psychotropic drug-free patients with MDD, aged 18-65 years. By using the Symptom Checklist-90 Items, Revised (SCL-90-R), a score of 4 (severe distress) on any one of three insomnia items was defined as severe insomnia. Other measures included the Montgomery-Asberg Depression Rating Scale (MADRS), the Fatigue Severity Scale (FSS), the nine psychopathology subscales of SCL-90-R, the Physical and Mental Component Summaries of Short Form Health Survey (SF-36 PCS and SF-36 MCS), and the Sheehan Disability Scale (SDS).
RESULTS: Of 528 participants, their mean age being 39.5 (SD=13.26) years, 64.2% were females, and 239 (45.3%) had severe insomnia. The logistic regression model revealed that low educational qualifications (less than secondary school completion), high SCL-90-R Depression scores, high SCL-90-R Anxiety scores, and low SF-36 PCS scores were independently correlated with severe insomnia (p's

Matched MeSH terms: Psychotropic Drugs/therapeutic use