MyMedR

Fulltext Retroperitoneal malignant fibrous histiocytoma with renal involvement

Sim PH, Razack AH, Pathmanathan R, Jalleh RP

Med J Malaysia, 1995 Jun;50(2):189-91.

Malignant fibrous histiocytoma is a mesenchymal tumour which can involve the genitourinary organs primarily or by secondary extension. Both conditions are rare. We report four cases of retroperitoneal malignant fibrous histiocytoma involving the kidney by local extension. Diagnosis was difficult because of diverse, non-specific clinical features and may only be reached at operation or post mortem. Prognosis is poor. Although en bloc tumour resection with nephrectomy was possible in two patients, they returned with recurrences.

Matched MeSH terms: Histiocytoma, Benign Fibrous/pathology; Histiocytoma, Benign Fibrous/radiography*; Histiocytoma, Benign Fibrous/surgery

Fulltext Sclerosing haemangioma of the lung

Liam CK, Wong KT

Singapore Med J, 1995 Jun;36(3):333-4.

PMID: 8553108

An asymptomatic middle-aged women was investigated for a lung nodule detected on routine chest X-ray. Percutaneous needle biopsy revealed it to be a sclerosing haemangioma which was subsequently removed by a left lower lobectomy. The literature on this uncommon benign lesion is reviewed.

Matched MeSH terms: Histiocytoma, Benign Fibrous/pathology; Histiocytoma, Benign Fibrous/radiography*; Histiocytoma, Benign Fibrous/surgery

Malignant fibrous histiocytoma in childhood

Hoe, T.S, Siti Aishah, M.A., Radzir, A.

Malaysian Journal of Child Health, 1994;6(1):46-48.

MyJurnal

We present a 12 year old girl with malignant fibrous histiocytoma and the suggested treat-ment of this rare condition would be excision of the tumour followed by systemic chemotherapy and local radiotherapy.

Matched MeSH terms: Histiocytoma, Benign Fibrous

Retroperitoneal malignant fibrous histiocytoma causing profuse bleeding per rectum

Sim PH, Pathmanathan R, Jalleh RP

Aust N Z J Surg, 1995 Jan;65(1):68-70.

PMID: 7818432

A case is reported of retroperitoneal malignant fibrous histiocytoma (MFH) invading into the colon, causing fresh bleeding per rectum. It illustrates the difficulty encountered in the pre-operative diagnosis of this condition, especially in a patient with an atypical presentation of profuse lower gastrointestinal bleeding.

Matched MeSH terms: Histiocytoma, Benign Fibrous/complications*; Histiocytoma, Benign Fibrous/pathology

Multiple clustered dermatofibroma presenting in a segmental distribution

Bhabha FK, Magee J, Ng SY, Grills CE, Su J, Orchard D

Australas J Dermatol, 2016 Feb;57(1):e20-2.

PMID: 25557526 DOI: 10.1111/ajd.12257

Multiple dermatofibromas is a rare entity consisting of more than fifteen lesions. Multiple clustered dermatofibroma is a distinct variant of multiple dermatofibromas and is defined as a well-demarcated plaque composed of individual dermatofibromas. We report a 16-year-old boy with multiple clustered dermatofibroma in a segmental distribution, which has previously not been reported in the literature.

Matched MeSH terms: Histiocytoma, Benign Fibrous/diagnosis; Histiocytoma, Benign Fibrous/pathology*

18F-FDG Uptake in Benign Fibrous Histiocytoma of Adrenal Gland: A Potential Pitfall

Tan TH, Lai CNB

Clin Nucl Med, 2017 Aug;42(8):622-623.

PMID: 28632691 DOI: 10.1097/RLU.0000000000001730

A 47-year-old man with newly diagnosed nasopharyngeal carcinoma underwent staging F-FDG PET/CT. Apart from showing increased FDG uptake in the primary site and locoregional nodal and liver metastases, an unusual site of intense FDG focus was demonstrated in the left adrenal gland. He underwent CT-guided biopsy, and the histopathologic diagnosis was benign fibrous histiocytoma.

Matched MeSH terms: Histiocytoma, Benign Fibrous/metabolism*

Fulltext Paraneoplastic Secretion of Multiple Phosphatonins From a Deep Fibrous Histiocytoma Causing Oncogenic Osteomalacia

Leow MKS, Dogra S, Ge X, Chuah KL, Liew H, Loke KSH, et al.

J Clin Endocrinol Metab, 2021 04 23;106(5):e2299-e2308.

PMID: 33462615 DOI: 10.1210/clinem/dgaa964

CONTEXT: Literature suggests that oncogenic osteomalacia is usually caused by a benign mesenchymal tumor secreting fibroblast growth factor subtype-23 (FGF-23), but the involvement of other phosphatonins has only been scarcely reported. We have previously published a seemingly typical case of oncogenic osteomalacia. Following curative neoplasm resection, we now report unique molecular characteristics and biology of this tumor.

CASE DESCRIPTION: A 25-year-old man had been diagnosed with severe oncogenic osteomalacia that gradually crippled him over 6 years. 68Ga-DOTA-TATE positron emission tomography/computed tomography scan localized the culprit tumor to his left sole, which on resection revealed a deep fibrous histiocytoma displaying a proliferation of spindle cells with storiform pattern associated with multinucleated giant cells resembling osteoclasts. Circulating FGF-23, which was elevated more than 2-fold, declined to undetectable levels 24 h after surgery. Microarray analysis revealed increased tumor gene expression of the phosphatonins FGF-23, matrix extracellular phosphoglycoprotein (MEPE) and secreted frizzled-related protein subtype 4, with elevated levels of all 3 proteins confirmed through immunoblot analysis. Differential expression of genes involved in bone formation and bone mineralization were further identified. The patient made an astonishing recovery from being wheelchair bound to fully self-ambulant 2 months postoperatively.

CONCLUSION: This report describes oncogenic osteomalacia due to a deep fibrous histiocytoma, which coincidentally has been found to induce profound muscle weakness via the overexpression of 3 phosphatonins, which resolved fully upon radical resection of the tumor. Additionally, genes involved in bone formation and bone remodeling contribute to the molecular signature of oncogenic osteomalacia.

Matched MeSH terms: Histiocytoma, Benign Fibrous/complications; Histiocytoma, Benign Fibrous/diagnosis; Histiocytoma, Benign Fibrous/genetics; Histiocytoma, Benign Fibrous/metabolism*

Intracranial angiomatoid fibrous histiocytoma with Hodgkin lymphoma

Gunness VRN, Munoz I, González-López P, Alshafai N, Mikalkova A, Spears J

Med J Malaysia, 2019 Jun;74(3):234-236.

PMID: 31256181

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour of uncertain differentiation and low metastatic potential, which occurs predominantly in children and young adults. It occurs mostly within the extremities, trunk, head and neck. We report the case of a 32-year-old female that was operated in our hospital in 2016 and twice in 2017. The patient had headaches and neck pain initially in 2016. We discuss the radiographic and histologic features initially found and the findings that ultimately led to the diagnosis of AFH. The patient had a past history of Hodgkin lymphoma.

Matched MeSH terms: Histiocytoma, Benign Fibrous

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