Trichosanthes cucumerina (Cucurbitaceae) commonly known as Snake gourd or Labu
Ular is considered the largest genre in the Cucurbitaceae family and is mainly found in the
southeast areas of Asia. It has been used in Ayurvedic medicine as a treatment for certain
diseases such as Diabetes mellitus, but these acclaims lack scientific-based evidence. In
this study, water and ethanol extracts of three parts of Trichosanthes cucumerina namely;
whole vegetable, peels, and seeds, were assessed for toxicity through a cell viability assay
using 3T3-L1 pre-adipocytes model which revealed a maximum toleration concentration
of 0.063 mg/mL. The extracts were further tested on adipocytes’ differentiation and
positively showed a stimulation of lipid droplets formation during adipogenesis and
significantly (p