MyMedR

Paper-thin roof: submucosal cleft palate with rhinolalia aperta

Tuang GJ, Zainal Abidin ZA

Postgrad Med J, 2021 Jul 21.

PMID: 34290122 DOI: 10.1136/postgradmedj-2021-140077

An Obstructed Malignant Inflammatory Myofibroblastic Tumour of the Rectum

Zainal Abidin ZA, Azizan N, Hayati F, Mra A, Mohd Azman ZA

Kathmandu Univ Med J (KUMJ), 2018 7 1;16(63):272-274.

PMID: 31719321

Inflammatory myofibroblastic tumour is rare but more common in children. It shows an immunophenotypic features of myofibroblastic differentiation, hence bearing neoplastic potential. The diagnosis is challenging especially if it involves rectum. Surgical resection is the mainstay of treatment if clinically obstructed. A 65-year-old gentleman presented with intestinal obstruction, which then followed by a hartmann's procedure. Final diagnosis is a rare case of inflammatory myofibroblastic tumour of the rectum. We discuss its genetic involvement with a literature review.

Fulltext Unilateral rhinorrhoea and button battery: a case report

Tuang GJ, Nik Hussin NR, Zainal Abidin ZA

Fam Med Community Health, 2019;7(3):e000137.

PMID: 32148716 DOI: 10.1136/fmch-2019-000137

Unilateral rhinorrhoea in the paediatric age group could be an alarming sign that warrants a clinician attention. These patients are routinely brought to see general practitioner as parents may not be aware of the urgency to intervene surgically. Herein we describe a case of a toddler who presented initially to a general practitioner with unilateral nasal discharge. He was subsequently referred to the otorhinolaryngology department for unresolved rhinitis. The child was examined, and the diagnosis of an embedded foreign body was made. X-ray of the paranasal sinus unveiled an embedded button battery. An emergency endoscopic retrieval of the button battery was performed under general anaesthesia. Unfortunately, the case was complicated with a huge septal perforation.

Biotransformation of sesquiterpenoids: a recent insight

Aminudin NI, Ridzuan M, Susanti D, Zainal Abidin ZA

J Asian Nat Prod Res, 2022 Feb;24(2):103-145.

PMID: 33783284 DOI: 10.1080/10286020.2021.1906657

Sesquiterpenoids have been identified as natural compounds showing remarkable biological activities found in medicinal plants. There is great interest in developing methods to obtain sesquiterpenoids derivatives and biotransformation is one of the alternative methods for structural modification of complex sesquiterpenes structures. Biotransformation is a great drug design tool offering high selectivity and green method. The present review describes a comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes. This review covers recent literatures from 2007 until 2020 and highlights the experimental conditions for each biotransformation process.

Case Report: Metastatic Neck Nodes of Unknown Origin with Concurrent Tuberculous Lymphadenitis. Is Fine Needle Aspiration and Cytology (FNAC) Adequate?

Subramaniam SD, Tuang GJ, Zainal Abidin ZA, Abdullah S

Indian J Otolaryngol Head Neck Surg, 2022 Dec;74(Suppl 3):5888-5892.

PMID: 36742794 DOI: 10.1007/s12070-021-02497-w

Presentation with cervical lymphadenopathy would usually have an aetiology of neoplasm, infection or reactive cause. Dual pathology of regional metastasis with simultaneous occurrence of tuberculous lymphadenopathy is rather rare. Herein the authors present a case of primary occult carcinoma and tuberculous lymphadenopathy in an unfortunate patient. The reliability of fine-needle aspiration cytology as a first-line investigation, with alternative methods in approaching cervical lymphadenopathy, was further dissected.

Fulltext Association of MMP-9 gene polymorphisms with nephrolithiasis patients

Mehde AA, Mehdi WA, Yusof F, Raus RA, Zainal Abidin ZA, Ghazali H, et al.

J Clin Lab Anal, 2018 Jan;32(1).

PMID: 28205286 DOI: 10.1002/jcla.22173

BACKGROUND: Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP-9 with nephrolithiasis patients.

METHODS: Genotyping of MMP-9/R279Q and of MMP-9/C1562T polymorphism were carried out by PCR-based restriction digestion method. Serum level of MMP-9, oxidative stress marker, MDA, and uric acid were measured in patients and control.

RESULTS: Allele frequencies of the MMP-9/C1562T polymorphism for C and T allele were 71.25% and 28.75% in patients, 87.08% and 12.92% in control respectively. The homozygote TT was more frequent in the nephrolithiasis patients group, while T allele frequency was significantly higher in the nephrolithiasis patients group than in the control group. The patients with CT and TT genotype showed a significant increase in serum MMP-9, Total Oxidant Status (TOS), Oxidative Stress Index (OSI), Malondialdehyde (MDA), and uric acid when compared to CC genotype in patients with nephrolithiasis. The R279Q polymorphism site with regard to the relationship with nephrolithiasis was not significant.

CONCLUSION: The result indicates that patients with TT genotype had an increased risk of stones. Also, the results demonstrate that TT allele of the C1562T polymorphism in the MMP-9gene is related with an increase of oxidative stress in nephrolithiasis patients and may possibly impose a risk for cardiovascular diseases in patients with TT genotype of MMP-9.

Fulltext Trapped cystofix: Laparoscopic modality to untie

Muhamad A, Johan S, Khairuddin A, Hayati F, Payus AO, Zainal Abidin ZA

Urol Case Rep, 2021 Jan;34:101448.

PMID: 33088720 DOI: 10.1016/j.eucr.2020.101448

Suprapubic catheterization (SPC) is a temporary measure to relieve acute urinary retention (AUR). Despite being effective, it can lead to complications such as colon perforation, haematuria, and bladder wall spasm. We present a 52-year-old lady with cystofix for underlying urethral stricture presented with AUR. A new SPC was inserted to drain the urine. However, the SPC had looped and entangled with her cystofix, and laparoscopic removal of cystofix and insertion of a new SPC was done. In conclusion, trapped cystofix to the SPC tube is a potential complication during SPC insertion that can be avoided with appropriate care.

Fulltext Nasopharyngeal carcinoma in dermatomyositis patients: A 10-year retrospective review in Hospital Selayang, Malaysia

Teoh JW, Yunus RM, Hassan F, Ghazali N, Abidin ZA

Rep Pract Oncol Radiother, 2014 Sep;19(5):332-6.

PMID: 25184058 DOI: 10.1016/j.rpor.2014.02.005

AIM: The objective of our review is to investigate the association between dermatomyositis patients and nasopharyngeal carcinoma (NPC) together with the clinical presentation of the patients and their management in otorhinolaryngology.
BACKGROUND: NPC is a malignant disease with good prognosis on early diagnosis. However, the relationship between the dermatomyositis and NPC and its management is not well defined.
MATERIALS AND METHODS: A 10-year retrospective review of case records of 21 dermatomyositis patients seen in Otorhinolaryngology Department of Hospital Selayang from January 2000 to November 2010.
RESULTS: These patients ranged from 19 to 74 years old and a total of 8 (38%) out of 21 adults with dermatomyositis were detected to have malignancy. Five out of 8 patients had NPC (62.5%). The mean age of patients with NPC and dermatomyositis was 48 years. NPC is diagnosed in 4 out of 5 patients (80%) in the first year of diagnosis of dermatomyositis. The clinical findings of the examination of nasopharynx ranged from hyperemia to exophytic nasopharyngeal mass. Histologically, it is only related to NPC of WHO types II and III.
CONCLUSIONS: There is a strong relationship between dermatomyositis and malignancy, especially NPC. Clinicians should have a high index of suspicion for malignancy in all dermatomyositis patients. Rigid nasoendoscopies and biopsies, serum Epstein-Barr viral capsid IgA antibody and imaging studies are helpful in detecting NPC in dermatomyositis patients.
KEYWORDS: Dermatomyositis; Epstein–Barr viral capsid IgA; Nasopharyngeal carcinoma; Paraneoplastic; WHO histology

Counter response to Response from Dr Wadhwani and Dr Rajesh to Gangrenous giant Meckel's diverticulitis masquerading acute appendicitis: a surgical conundrum

Hayati F, Azizan N, Yeap BT, Zainal Abidin ZA, Zakaria AD

ANZ J Surg, 2020 01;90(1-2):188-189.

PMID: 32067312 DOI: 10.1111/ans.15577

Biotransformation of curcumin by Streptomyces sp. K1-18 isolated from mangrove soil

Aminudin NI, Wan Jaafar WMS, Mohd Amin NMS, Kamarul Baharin R, Zainal Abidin ZA

Nat Prod Res, 2024 Feb 19.

PMID: 38372293 DOI: 10.1080/14786419.2024.2318786

Biotransformation is recognised as a green chemistry tool to synthesise diverse natural product analogues for valorisation of their chemistry and bioactivities. It offers significant benefits compared to chemical synthesis, given its cost-effectiveness and greater selectivity. In this work, a curcumin analogue, namely gingerenone A, was yielded from the biotransformation process catalysed by Streptomyces sp. K1-18. The structure of the compound was established by using mass spectrometry/mass spectrometry chemical profiling assisted with in silico fragmentation by MetFrag tool. This biotransformation successfully afforded a reduction reaction on curcumin. This is the first report on utilisation of Streptomyces sp. K1-18 as a biocatalyst for biotransformation of curcumin.

Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger

Aminudin NI, Abdul Aziz AA, Zainal Abidin ZA, Susanti D, Taher M

Nat Prod Res, 2024 May;38(9):1583-1590.

PMID: 36577029 DOI: 10.1080/14786419.2022.2161543

Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7 R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst.

Fulltext Social Media in the Urology Practice | Opinion: NO

Da Silva RD, Leow JJ, Abidin ZA, Linden-Castro E, Castro EIB, Blanco LT, et al.

Int Braz J Urol, 2019 10 19;45(5):882-888.

PMID: 31626517 DOI: 10.1590/S1677-5538.IBJU.2019.05.04

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