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Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Sharifi-Rad J 1 , Quispe C 2 , Mukazhanova Z 3 , Knut E 4 , Turgumbayeva A 5 , Kipchakbayeva A 6 Show all authors , Seitimova G 6 , Mahomoodally MF 7 , Lobine D 7 , Koay A 8 , Wang J 8 , Sheridan H 8 , Leyva-Gómez G 9 , Prado-Audelo MLD 9 , Cortes H 10 , Rescigno A 11 , Zucca P 11 , Sytar O 12 , Imran M 13 , Rodrigues CF 14 , Cruz-Martins N 15 , Ekiert H 4 , Kumar M 16 , Abdull Razis AF 17 , Sunusi U 18 , Kamal RM 18 , Szopa A 4

Affiliations 

  • 1 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 2 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile
  • 3 Department of Natural Sciences and Technologies, Sarsen Amanzholov East Kazakhstan State University, Ust-Kamenogorsk, Kazakhstan
  • 4 Chair and Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland
  • 5 Asfendiyarov Kazakh National Medical University, School Pharmacy, Almaty, Kazakhstan
  • 6 Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
  • 7 Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
  • 8 Trinity College Dublin, NatPro (Natural Products Research Centre), School of Pharmacy and Pharmaceutical Science, Dublin, Ireland
  • 9 Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico City, Mexico
  • 10 Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico City, Mexico
  • 11 Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Cagliari, Italy
  • 12 Department of Plant Biology, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  • 13 University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
  • 14 Laboratory for Process Engineering, Environment, Biotechnology and Energy-Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal
  • 15 Faculty of Medicine, University of Porto, Porto, Portugal
  • 16 Chemical and Biochemical Processing Division, ICAR - Central Institute for Research on Cotton Technology, Mumbai, India
  • 17 Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia
  • 18 Natural Medicines and Products Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
Front Mol Biosci, 2021;8:649395.
PMID: 34540888 DOI: 10.3389/fmolb.2021.649395

Abstract

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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