Introduction: Platelet aggregation test using light transmission aggregometry (LTA) is considered as the gold
standard for evaluation of platelet function. Variations of platelet aggregation had been reported in apparently
healthy individuals whereby a normal cut–off value established locally is highly recommended. This study aims
to determine the platelet aggregation pattern and the preliminary findings on reference values for
multiple agonists–induced platelet aggregation among Malaysian healthy individuals in a single centre.
Method: A total number of 63 informed consented healthy individuals consisted of Malay, Chinese and Indian
were recruited among staff and blood donors at National Blood Centre, Kuala Lumpur. Platelet aggregation was
measured using LTA against adenosine diphosphate 10 µM (ADP10), collagen 0.19 mg/mL (COL), ristocetin 1.5
mg/mL (RIS), arachidonic acid 1 mM (AA) and epinephrine 10 µM (EPI). Results were expressed as percent final
aggregation (%FA). Reference values were calculated from mean±2SD. Results: Age, gender and ethnic groups had
no significant effect on platelet aggregation. A variability of platelet aggregation response to EPI was observed among
the healthy individuals. Ten of 33 respondents (30%) had impaired aggregation with