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Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats

Dhiyaaldeen SM 1 , Amin ZA 2 , Darvish PH 3 , Mustafa IF 4 , Jamil MM 5 , Rouhollahi E 6 Show all authors , Abdulla MA 7

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
  • 2 Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, 44001, Erbil, Iraq. [email protected]
  • 3 Department of Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
  • 4 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
  • 5 Center of studies for Periodontology, Faculty of Denistry, University Teknologi Mara, 40450, Shah Alam, Malaysia. [email protected]
  • 6 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
  • 7 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. [email protected]
BMC Vet Res, 2014;10:961.
PMID: 25551777 DOI: 10.1186/s12917-014-0303-7

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) can result in peptic ulcer disease (PUD) which is a common condition worldwide. The aim of this study was to evaluate the antiulcer properties of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone) (HPTP) chalcone in rats using indomethacin as ulcerogenic agent.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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