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The analysis of clinical and laboratory data: a large outbreak of dengue fever in Chaozhou, Guangdong province, China

Lin F 1 , Yang H 2 , Zhang L 1 , Fang SH 1 , Zhan XF 1 , Yang LY 3

Affiliations 

  • 1 Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, 521021, Guangdong, China
  • 2 Department of Laboratory Medicine, School of Medicine, Yangtze University, Jingzhou, Hubei, China
  • 3 Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, 521021, Guangdong, China. [email protected]
Arch Virol, 2019 Aug;164(8):2131-2135.
PMID: 31102050 DOI: 10.1007/s00705-019-04266-1

Abstract

A large-scale dengue fever (DF) outbreak occurred in Chaozhou, Guangdong province, China 2015. In our study, 528 dengue-positive patient samples were collected for clinical and laboratory data analysis. 491 cases (93.0%) were primary dengue fever (PDF), 22 cases (4.2%) were dengue hemorrhagic fever (DHF) and 15 cases (2.8%) were diagnosed with severe dengue fever (SDF). All cases were infected by dengue virus serotype 2 (DENV-2), and the isolated strains belonged to cosmopolitan genotype, which were grouped closely with Malaysia strains from 2010 to 2014. Moreover, the study showed that laboratory indices have significantly difference in PDF, DHF and SDF patients. A comprehensive analysis of these data could assist and guide the clinical diagnosis for DF, which has an important significance for the control of dengue virus infection.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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