Implication of CDKAL1 single-nucleotide polymorphism rs 9465871 in obese and non-obese Egyptian children

Ismail NA 1 , Ragab S 2 , Abd El Dayem SM 3 , Baky ANAE 3 , Hamed M 2 , Ahmed Kamel S 2 Show all authors , Adel El Halim D 2

Affiliations 

  • 1 National Research Centre, Medical Division, Pediatric Department, Cairo, Egypt. [email protected]
  • 2 National Research Centre, Medical Division, Clinical & Chemical Pathology Department, Cairo, Egypt
  • 3 National Research Centre, Medical Division, Pediatric Department, Cairo, Egypt
Med J Malaysia, 2018 10;73(5):286-290.
PMID: 30350806

Abstract

INTRODUCTION: CDKAL1 single-nucleotide polymorphism rs 9465871variant is a risk locus for Type 2 Diabetes (T2DM).The study evaluated the associations of CDKAL1- rs9465871 with glycosylated hemoglobin A1C Level (HbA1c), fasting insulin level, insulin resistance and metabolic syndrome among obese and non- obese Egyptian children.

MATERIALS AND METHODS: The study included 43 obese children and 40 normal weight children. Anthropometric body measurements, bio-specimen and biochemistry assays were done. Genotyping of rs9465871 (CDKAL1) was conducted.

RESULTS: The percentages of the CC, CT, and TT genotypes of rs9465871in the lean children were 15%, 42.5%, and 42.5%, respectively. Regarding obese children, the frequencies were 18.6%, 58.1% and 23.3% respectively with no significant statistical difference. Comparison between the CDKAL1 rs 9465871 polymorphism showed that the highest value of fasting insulin was recorded in CC genotype (22.80± 15.18 [uIU/mL] P

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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