Advancements in electrochemical DNA sensor for detection of human papilloma virus - A review

Rasouli E 1 , Shahnavaz Z 2 , Basirun WJ 3 , Rezayi M 4 , Avan A 5 , Ghayour-Mobarhan M 6 Show all authors , Khandanlou R 7 , Johan MR 8

Affiliations 

  • 1 Nanotechnology & Catalysis Research Centre, Institute of Postgraduate Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: [email protected]
  • 2 Nanotechnology & Catalysis Research Centre, Institute of Postgraduate Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: [email protected]
  • 3 Nanotechnology & Catalysis Research Centre, Institute of Postgraduate Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: [email protected]
  • 4 Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected]
  • 5 Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected]
  • 6 Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected]
  • 7 School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University, 3350, Ballarat, Australia. Electronic address: [email protected]
  • 8 Nanotechnology & Catalysis Research Centre, Institute of Postgraduate Studies, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: [email protected]
Anal Biochem, 2018 09 01;556:136-144.
PMID: 29981317 DOI: 10.1016/j.ab.2018.07.002

Abstract

Human papillomavirus (HPV) is one of the most common sexually transmitted disease, transmitted through intimate skin contact or mucosal membrane. The HPV virus consists of a double-stranded circular DNA and the role of HPV virus in cervical cancer has been studied extensively. Thus it is critical to develop rapid identification method for early detection of the virus. A portable biosensing device could give rapid and reliable results for the identification and quantitative determination of the virus. The fabrication of electrochemical biosensors is one of the current techniques utilized to achieve this aim. In such electrochemical biosensors, a single-strand DNA is immobilized onto an electrically conducting surface and the changes in electrical parameters due to the hybridization on the electrode surface are measured. This review covers the recent developments in electrochemical DNA biosensors for the detection of HPV virus. Due to the several advantages of electrochemical DNA biosensors, their applications have witnessed an increased interest and research focus nowadays.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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