Preparation and Characterization of Magnetite-Polyvinyl Alcohol Hybrid Nanoparticles (As-PVA-MNPs) Using Acanthophora spicifera Marine Algae Extract for Enhanced Antimicrobial Activity Against Pathogenic Microorganisms

Kumar DSRS 1 , Puthiran SH 2 , Selvaraju GD 3 , Matthew PA 4 , Senthilkumar P 2 , Kuppusamy S 5 Show all authors , Mani RR 6 , Hatamleh AA 7 , Ai-Dosary MA 7 , Chang SW 8 , Ravindran B 9

Affiliations 

  • 1 Department of Biotechnology, PSGR krishnammal College for Women, Coimbatore, Tamil Nadu, 641004, India. [email protected]
  • 2 School of Biotechnology, Dr. G. R. Damodaran College of Science, Coimbatore, Tamil Nadu, 641014, India
  • 3 Department of Biotechnology, KIT-Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, 641402, India
  • 4 School of Bioscience and Technology, VIT- Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India
  • 5 PG and Research Department of Biotechnology & Bioinformatics, Holy Cross College, Tiruchirappalli, Tamil Nadu, 620002, India
  • 6 Faculty of Pharmaceutical Sciences, UCSI University, 56000, Cheras, Kuala Lumpur, Malaysia
  • 7 Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, 1155, Riyadh, Saudi Arabia
  • 8 Department of Medical Biotechnology and Integrative Physiology, Institute of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India
  • 9 Department of Medical Biotechnology and Integrative Physiology, Institute of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India. [email protected]
Mol Biotechnol, 2023 Oct 31.
PMID: 37907811 DOI: 10.1007/s12033-023-00903-y

Abstract

The present study focused on preparing and characterizing magnetite-polyvinyl alcohol (PVA) hybrid nanoparticles using Acanthophora spicifera marine algae extract as a reducing agent. Various analytical techniques, including UV-Visible spectrometry, Fourier-transform infrared (FTIR) analysis, energy-dispersive X-ray (EDX), scanning electron microscopy (SEM), and X-ray diffraction (XRD) analysis, were used to characterize the nanoparticles. The results showed the successful synthesis of nanoparticles with a characteristic color change and absorption peak at 400 nm in UV-Visible spectrometry. FTIR analysis indicated an interaction between the carboxyl group and magnetite-polyvinyl alcohol hybrid ions. SEM analysis revealed spherical nanoparticles with sizes ranging from 20 to 100 nm. EDX analysis confirmed the presence of strong magnetite peaks in Acanthophora spicifera, validating successful preparation. XRD analysis indicated the crystalline nature of the nanoparticles. Furthermore, the antimicrobial potential of As-PVA-MNPs was evaluated, demonstrating a significant zone of inhibition against tested bacterial and fungal samples at a concentration of 100 µg. These findings suggest the promising antimicrobial activity of the synthesized nanoparticles for potential applications in combating pathogenic microorganisms.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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