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Multiple Cemento-Ossifying Fibroma: A Sign of Hyperparathyroidism-Jaw Tumour Syndrome

Apandi NIM 1 , Basri NN 2 , Jalil AA 3 , Jelon MA 4

Affiliations 

  • 1 Department of Diagnostics and Craniofacial Biosciences, Faculty of Dentistry, The National University of Malaysia, Kuala Lumpur, Malaysia
  • 2 Oral Pathology and Oral Medicine Unit, Department of Oral & Maxillofacial Surgery, Kuala Lumpur Hospital, Ministry of Health, Kuala Lumpur, Malaysia
  • 3 Stomatology Unit, National Institute of Health, Ministry of Health, Setia Alam, 40170 Shah Alam, Selangor, Malaysia
  • 4 Oral and Maxillofacial Surgery Unit, Department of Oral & Maxillofacial Surgery, Kuala Lumpur Hospital, Ministry of Health, Kuala Lumpur, Malaysia
Case Rep Dent, 2023;2023:4664619.
PMID: 36937223 DOI: 10.1155/2023/4664619

Abstract

Hyperparathyroidism-jaw tumour (HPT-JT) syndrome is a rare autosomal dominant disease. It is caused by a gene mutation of the tumour suppressor gene CDC73 that encodes for parafibromin. This syndrome predisposes to a triad occurrence of multiple maxillary or mandibular cemento-ossifying fibroma, parathyroid adenoma or carcinoma, and renal and uterine tumours. In this study, we report a case of HPT-JT occurring in a 30-year-old male patient.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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